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Characterization of intronic SNP located in candidate genes influencing cattle temperament
Ruiz-De-La-Cruz, Gilberto; Sifuentes-Rincón, Ana María; Paredes-Sánchez, Francisco Alejandro; Parra-Bracamonte, Gaspar Manuel; Casas, Eduardo; Welsh Junior, Thomas H; Riley, David Greg; Perry, George; Randel, Ronald D.
Afiliação
  • Ruiz-De-La-Cruz, Gilberto; Instituto Politécnico Nacional. Laboratorio de Biotecnología Animal. Reynosa. MX
  • Sifuentes-Rincón, Ana María; Instituto Politécnico Nacional. Laboratorio de Biotecnología Animal. Reynosa. MX
  • Paredes-Sánchez, Francisco Alejandro; Universidad Autónoma de Tamaulipas. Unidad Académica Multidisciplinaria Mante. El Mante. MX
  • Parra-Bracamonte, Gaspar Manuel; Instituto Politécnico Nacional. Laboratorio de Biotecnología Animal. Reynosa. MX
  • Casas, Eduardo; United States Department of Agriculture. Agricultural Research Service. Ames. US
  • Welsh Junior, Thomas H; Texas A&M University. Department of Animal Science. College Station. US
  • Riley, David Greg; Texas A&M University. Department of Animal Science. College Station. US
  • Perry, George; Texas A&M University. Overton. US
  • Randel, Ronald D; Texas A&M University. Overton. US
Rev. bras. zootec ; 52: e20220057, 2023. tab, graf, ilus
Article em En | VETINDEX | ID: biblio-1449866
Biblioteca responsável: BR68.1
ABSTRACT
The objective of this study was to evaluate the effect of intronic single nucleotide polymorphisms (SNP) on temperament traits in a Brahman cattle population. The SNP located in CACNG4, EXOC4, NRXN3, and SLC9A4 candidate genes were genotyped in 250 animals with temperament records of exit velocity, pen score, and temperament score. Rs3423464051G>A in the CACNG4 gene was associated with exit velocity and temperament score. An in silico analysis of the five intronic SNP showed that alternative alleles of CACNG4-rs3423464051, EXOC4-rs109393235, and SLC9A4-rs109722627 SNP could alter branch point sites during splicing, while a protein-protein interaction network analysis demonstrated a GRIA2 gene-mediated interaction between CACNG4 and NRXN3. The present results support previously reported evidence regarding bovine temperament-related candidate genes, particularly CACNG4, which is a confirmed candidate gene in need of more detailed analyses to reveal its role in temperament-related traits.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Comportamento Animal / Bovinos / Polimorfismo de Nucleotídeo Único Limite: Animals Idioma: En Revista: Rev. bras. zootec Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Comportamento Animal / Bovinos / Polimorfismo de Nucleotídeo Único Limite: Animals Idioma: En Revista: Rev. bras. zootec Ano de publicação: 2023 Tipo de documento: Article