Soybean -conglycinin Induces Intestinal Immune Responses in Chicks
Rev. bras. ciênc. avic
; 22(2): eRBCA, 2020. ilus, tab, graf
Article
em En
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| ID: biblio-1490768
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Conglycinin from soybean has been recognized as one of the major feed allergens. This study investigated the effects of -conglycinin-induced allergic sensitization on chicks small intestines. A total of 40 7-day-old (100 g) chicks were divided into four groups as control, -conglycinin 1 h, -conglycinin 6 h, and -conglycinin 12 h. All treatment groups were administered 60 mg of -conglycinin/chick and small intestine samples were collected. -conglycinin-induced allergic sensitization marginally damages the epithelium lining of the duodenum villi and, in addition, significantly increases the accumulation of mast cells in the lamina propria and crypt of the duodenum. Moreover, the TNF- level significantly increased in all -conglycinin groups. IL-8 and IL-2 were significantly downregulated in the 1 h group; however, there were increases for the 6 h and 12 h groups. These results suggest that -conglycinin may lead to an inflammatory response in the chicks small intestines.
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Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Galinhas
/
Imunidade nas Mucosas
/
Proteínas de Soja
Limite:
Animals
Idioma:
En
Revista:
Rev. bras. ciênc. avic
Ano de publicação:
2020
Tipo de documento:
Article