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Talc slurry versus thoracoscopic talc insufflation for malignant pleural effusion: a systematic review and meta-analysis
Rodrigues, Anna Luíza Soares de Oliveira; Souza, Maria Eduarda Cavalcanti; Moraes, Francisco Cezar Aquino de; Lima, David Paes de; Carvalho, Rafael Lucas Costa de.
Afiliação
  • Rodrigues, Anna Luíza Soares de Oliveira; Centro Universitário de João Pessoa. João Pessoa. BR
  • Souza, Maria Eduarda Cavalcanti; Universidade de Pernambuco. Recife. BR
  • Moraes, Francisco Cezar Aquino de; Universidade Federal do Pará. Belém. BR
  • Lima, David Paes de; Universidade de São Paulo. Instituto do Coração. Divisão de Cirurgia Torácica. São Paulo. BR
  • Carvalho, Rafael Lucas Costa de; Universidade de São Paulo. Instituto do Coração. Divisão de Cirurgia Torácica. São Paulo. BR
J. bras. pneumol ; 50(3): e20240115, 2024. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1569306
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Objective:

Talc pleurodesis is a widely used treatment option for malignant pleural effusion (MPE). However, the optimal form of administration remains controversial. Thus, we performed a systematic review and meta-analysis to assess the effectiveness of talc slurry (TS) in comparison with thoracoscopic talc insufflation/poudrage (TTI) for MPE treatment.

Methods:

We searched PubMed, EMBASE, and Cochrane Library databases for studies that compared TS with TTI in patients with MPE. We used a random-effects model with a 95% CI to pool the data. Heterogeneity was assessed with I2 statistics.

Results:

We included eight studies involving 1,163 patients, 584 of whom (50.21%) underwent TS. Pleurodesis failure rates were similar between the procedures (OR = 1.07; 95% CI 0.56-2.06; p = 0.83; I2 = 62%); and 68% of patients (95% CI 0.31-1.47; p = 0.33; I2 = 58%) had postoperative complications, which were lower in patients in the TS group than in the TTI group. In a subgroup analysis considering only randomized clinical trials, the failure rate was significantly lower in the TS treatment group (OR = 0.62; 95% CI 0.42-0.90; p = 0.01; I2 = 0%). Similarly, dyspnea was less common in the TS group (OR = 0.74; 95% CI 0.41-1.34; p = 0.32; I2 = 55%). Adverse effects were reported in 86 patients, and no significant difference was seen between the TS and TTI groups empyema (OR = 1.43; 95% CI 0.36-5.64; p = 0.86; I2 = 0%), pain (OR = 1.22 (95% CI 0.67-2.21; p = 0.51; I2 = 38%), and pneumonia (OR = 1.15; 95% CI 0.30-4.46; p = 0.86; I2 = 27%).

Conclusions:

Our findings suggest that TS is an effective treatment for MPE, with no significant increase in adverse events. Results suggest equivalent efficacy and safety for both procedures.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: J. bras. pneumol Assunto da revista: PNEUMOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: J. bras. pneumol Assunto da revista: PNEUMOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil