Clinical spectrum of congenital Zika virus infection in Brazil: Update and issues for research development

Martelli, Celina Maria Turchi; Cortes, Fanny; Brandão-Filho, Sinval Pinto; Turchi, Marilia Dalva; Souza, Wayner Vieira de; Araújo, Thalia Velho Barreto de; Ximenes, Ricardo Arraes de Alencar; Miranda-Filho, Demócrito de Barros

Martelli, Celina Maria Turchi; Cortes, Fanny; Brandão-Filho, Sinval Pinto; Turchi, Marilia Dalva; Souza, Wayner Vieira de; Araújo, Thalia Velho Barreto de; Ximenes, Ricardo Arraes de Alencar; Miranda-Filho, Demócrito de Barros.

Afiliação

Martelli, Celina Maria Turchi; Instituto Aggeu Magalhães. Programa de Pós-Graduação em Saúde Pública. Recife. BR
Cortes, Fanny; Universidade de Pernambuco. Pós-Graduação em Ciências da Saúde. Recife. BR
Brandão-Filho, Sinval Pinto; Instituto Aggeu Magalhães. Departamento de Imunologia. Recife. BR
Turchi, Marilia Dalva; Universidade Federal de Goiás. Programa de Pós-Graduação em Medicina Tropical e Saúde Pública. Goiânia. BR
Souza, Wayner Vieira de; Instituto Aggeu Magalhães. Programa de Pós-Graduação em Saúde Pública. Recife. BR
Araújo, Thalia Velho Barreto de; Universidade Federal de Pernambuco. Programa de Pós-Graduação em Saúde Coletiva. Recife. BR
Ximenes, Ricardo Arraes de Alencar; Universidade de Pernambuco. Pós-Graduação em Ciências da Saúde. Recife. BR
Miranda-Filho, Demócrito de Barros; Universidade de Pernambuco. Pós-Graduação em Ciências da Saúde. Recife. BR

Rev. Soc. Bras. Med. Trop ; 57: e00301, 2024. graf

Article em En | LILACS-Express | LILACS | ID: biblio-1569572

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

ABSTRACT This review aimed to provide an update on the morphological and/or functional abnormalities related to congenital Zika virus (ZIKV) infection, based on primary data from studies conducted in Brazil since 2015. During the epidemic years (2015-2016), case series and pediatric cohort studies described several birth defects, including severe and/or disproportionate microcephaly, cranial bone overlap, skull collapse, congenital contractures (arthrogryposis and/or clubfoot), and visual and hearing abnormalities, as part of the spectrum of Congenital Zika Syndrome (CZS). Brain imaging abnormalities, mainly cortical atrophy, ventriculomegaly, and calcifications, serve as structural markers of CZS severity. Most case series and cohorts of microcephaly have reported the co-occurrence of epilepsy, dysphagia, orthopedic deformities, motor function impairment, cerebral palsy, and urological impairment. A previous large meta-analysis conducted in Brazil revealed that a confirmed ZIKV infection during pregnancy was associated with a 4% risk of microcephaly. Additionally, one-third of children showed at least one abnormality, predominantly identified in isolation. Studies examining antenatally ZIKV-exposed children without detectable abnormalities at birth reported conflicting neurodevelopmental results. Therefore, long-term follow-up studies involving pediatric cohorts with appropriate control groups are needed to address this knowledge gap. We recognize the crucial role of a national network of scientists collaborating with international research institutions in understanding the lifelong consequences of congenital ZIKV infection. Additionally, we highlight the need to provide sustainable resources for research and development to reduce the risk of future Zika outbreaks.

Palavras-chave

Brazil; Congenital Zika Syndrome; Congenital Zika Virus Infection; Review

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev. Soc. Bras. Med. Trop Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil

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