A study on reducing the absorption of lidocaine from the airway in cats
Acta cir. bras
; 32(8): 662-672, Aug. 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-886229
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To determine if the combination of lidocaine with epinephrine or gamma globulin would decrease the rate or reduce the amount of local absorption of lidocaine through the airway.Methods:
Twenty adult male cats were randomly and evenly distributed into four groups 1) Group LG lidocaine administered with gamma globulin; 2) Group LS lidocaine administered with physiological saline); 3) Group LE lidocaine administered with epinephrine; 4) Group C control group. Invasive blood pressure, heart rate, and concentration of lidocaine were recorded before and after administration.Results:
The peak of plasma concentrations appeared difference (Group LG 1.39 ± 0.23 mg/L; Group LS 1.47 ± 0.29 mg/L and Group LE 0.99 ± 0.08 mg/L). Compared to Group C, there were significant differences in the average heart rate of Groups LG, LS, and LE (P < 0.05). The average systolic blood pressures were significantly different when each group was compared to Group C (P < 0.05). The biological half-life, AUC0-120, peak time, and half-life of absorption among the three groups have not presented statistically significant differences (P > 0.05).Conclusion:
Administering lidocaine in combination with gamma globulin through airway causes significant decrease the rate and reduce the amount of local absorption of lidocaine in cats.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Gama-Globulinas
/
Epinefrina
/
Agonistas Adrenérgicos beta
/
Absorção pelo Trato Respiratório
/
Anestésicos Locais
/
Lidocaína
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Brasil