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Acetaminophen mitigates myocardial injury induced by lower extremity ischemia-reperfusion in rat model
Geldi, Onur; Kubat, Emre; Ünal, Celal Selçuk; Canbaz, Suat.
Afiliação
  • Geldi, Onur; Zonguldak Atatürk State Hospital. Department of Cardiovascular Surgery. Zonguldak. TR
  • Kubat, Emre; Karabük Training and Research Hospital. Department of Cardiovascular Surgery. Karabük. TR
  • Ünal, Celal Selçuk; Karabük Training and Research Hospital. Department of Cardiovascular Surgery. Karabük. TR
  • Canbaz, Suat; Trakya University Faculty of Medicine. Department of Cardiovascular Surgery. Edirne. TR
Rev. bras. cir. cardiovasc ; 33(3): 258-264, May-June 2018. tab, graf
Article em En | LILACS | ID: biblio-958409
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Objective:

The injury-reducing effect of acetaminophen, an effective analgesic and antipyretic on ischemia-reperfusion continues to attract great attention. This study analyzed the protective effect of acetaminophen on myocardial injury induced by ischemia-reperfusion in an experimental animal model from lower extremity ischemia-reperfusion.

Methods:

Twenty-four Sprague-Dawley female rats were randomized into three groups (n=8) as (i) control group (only laparotomy), (ii) aortic ischemia-reperfusion group (60 min of ischemia and 120 min of reperfusion) and (iii) ischemia-reperfusion + acetaminophen group (15 mg/kg/h intravenous acetaminophen infusion starting 15 minutes before the end of the ischemic period and lasting till the end of the reperfusion period). Sternotomy was performed in all groups at the end of the reperfusion period and the heart was removed for histopathological examination. The removed hearts were histopathologically investigated for myocytolysis, polymorphonuclear leukocyte (PMNL) infiltration, myofibrillar edema and focal hemorrhage.

Results:

The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).

Conclusion:

Acetaminophen is considered to have cardioprotective effect in rats, by reducing myocardial injury induced by abdominal aortic ischemia-reperfusion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Cardiotônicos / Traumatismo por Reperfusão Miocárdica / Extremidade Inferior / Acetaminofen Tipo de estudo: Clinical_trials / Evaluation_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Rev. bras. cir. cardiovasc Assunto da revista: CARDIOLOGIA / CIRURGIA GERAL Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Cardiotônicos / Traumatismo por Reperfusão Miocárdica / Extremidade Inferior / Acetaminofen Tipo de estudo: Clinical_trials / Evaluation_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Rev. bras. cir. cardiovasc Assunto da revista: CARDIOLOGIA / CIRURGIA GERAL Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil