Tratamiento de la osteoporosis grave con teriparatide. / [Severe osteoporosis treatment with teriparatide].
Medicina (B Aires)
; 73(5): 428-32, 2013.
Article
em Es
| BINACIS
| ID: bin-132909
ABSTRACT
The primary objective of this retrospective study was to evaluate the treatment of severe osteoporosis with teriparatide (PTH) and to compare our results with those published in the literature. We included 46 patients, 42 women and four men, mean age 69.15 ± 9.43 years. Six patients were treatment naive and forty previously treated with bisphosphonates. Thirty-two patients had had 93 fractures of which 86 vertebral. Forty-six received PTH for 6 months, twenty-nine for 12 months and twenty completed the 18 months suggested. Bone mineral density (BMD) of the lumbar spine increased significantly at the first control performed at six months of treatment (p < 0.0001), and the femoral neck BMD reached a significant increase at the end of treatment (p = 0.002). Serum osteocalcin values significantly increased from the first month of treatment, followed by ÎÆ crosslaps (beta-CTx, serum test) and bone-specific alkaline phosphatase, returning all the markers of bone turnover to baseline levels at 18 months. Serum and urinary calcium did not change significantly at any time, but 8 (17.9
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Osteoporose
/
Teriparatida
/
Conservadores da Densidade Óssea
Tipo de estudo:
Evaluation_studies
/
Observational_studies
Limite:
Aged80
Idioma:
Es
Revista:
Medicina (B Aires)
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
Argentina