Interleukin-2 restores natural killer activity inhibited by sera from HIV + Hemophilic patients
Medicina [B.Aires]
; 59(2): 162-6, 1999. tab
Article
em En
| BINACIS
| ID: bin-16201
Biblioteca responsável:
BR1.1
ABSTRACT
Natural killer (NK) activity is impaired in patients with positive serology for the human immunodeficiency virus (HIV). We previously found an inhibitory effect of sera from hemophilic (He) HIV+ patients on normal NK activity. In the present study, we have further characterized this effect by studying its reversibility, temperature and time incubation dependence. Since interleukin 2 (IL-2) is able to enhance NK levels, we analized the capacity of this lymphokine to reverse the effect of He HIV+ sera. We found that when IL-2 activation of NK activity occurred simultaneously or after HIV+ serum-treatment, a significant restoration of NK function was observed. In contrast, preincubation with IL-2 did not affect the inhibitory effect exerted by HIV+ sera. (AU)
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Células Matadoras Naturais
/
Infecções por HIV
/
Interleucina-2
/
Hemofilia A
Limite:
Humans
Idioma:
En
Revista:
Medicina [B.Aires]
Ano de publicação:
1999
Tipo de documento:
Article