The benefits of 7.5 NaCl/6 dextran 70 (HSD) for prehospital resuscitation of hemorrhagic shock: improved oxygen transport
Braz. j. med. biol. res
; 22(2): 275-8, 1989. tab
Article
em En
| LILACS
| ID: lil-105564
Biblioteca responsável:
BR1.1
ABSTRACT
The purpose of this study was to compare the benefit of small volume hyperonic saline/dextran (HSD) versus the risk of obligatory time to administer it on-scene in a model of acute hemorrhagic shock. Dogs were bled to a mean arteiral pressure (MAP) of 20 mmHg and the randomized to either a) direct transport to the emergency department (ED) or b) 10 min delay to insert an iv HSD (4 ml/Kg) infusion over 5 min, and then transport. The animals receiving HSD had improved (P<0.05) cardiac work and oxigen consumption during transport (MAP = 59 ñ 3 vs 38 ñ 4 mmHg; cardiac index (CI) = 3.2 ñ 0.2 vs 1.3 ñ 0.1 L min-1 M-2; O2CI = 115 ñ 7 vs 104 ñ 7 mlmin-1M-2), paralleled by reduced serum lactate (5.3 ñ 0.8 vs 7.0 ñ 2.3 mmol/L) and decreased metabolic acidosis. The benefitsof HSD in attenuating shock-induced oxygen debt were corroborated by lower O2CI(98 ñ 4 vs 112 ñ 5 ml min-1 M-2) and higher pH (7.30 ñ 0.01 vs 7.24 ñ 0.02) in the postresuscitation period
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Consumo de Oxigênio
/
Ressuscitação
/
Choque Hemorrágico
/
Transporte de Pacientes
/
Serviços Médicos de Emergência
/
Hidratação
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1989
Tipo de documento:
Article
/
Congress and conference
País de publicação:
Brasil