Induction of mitogenesis by synthetic peptides related to the structure of human fibroblast growth factor-1
Ciênc. cult. (Säo Paulo)
; 48(5/6): 359-60, Sept.-Dec. 1996. tab
Article
em En
| LILACS
| ID: lil-186336
Biblioteca responsável:
BR1.1
RESUMO
The synthetic peptide Ac-WFVGLKKNGSSKRGPRT-NH2,related to the human FGF-1 sequence, was shown to be mitogenic upon Balb/c 3T3 fibroblasts in culture (ED50=10-20 muM) and to compete with the growth factor for cellular binding (ID50 = 30-50 muM). The results described suggest that the mitogenic activity of the peptide is dependent on the presence of the residues 122-127 (WFVGLK) in its structure. Also, its affinity for the cellular receptors seems to be dependent on the presence of residues that are important for FGF-heparin binding such as K127, K133 and R137.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Peptídeos
/
Fatores de Crescimento de Fibroblastos
/
Mitose
Limite:
Animals
Idioma:
En
Revista:
Ciênc. cult. (Säo Paulo)
Assunto da revista:
CIENCIA
Ano de publicação:
1996
Tipo de documento:
Article
País de publicação:
Brasil