Lipids, apoliprotein-E genotypes and other risk factors of patients with coronary artery disease in Curacao
West Indian med. j
; 46(2): 47-52, June 1997.
Article
em En
| LILACS
| ID: lil-193508
Biblioteca responsável:
JM3.1
ABSTRACT
We studied lipids, apolipoprotein-E (apo-E) genotypes and other coronary artery disease (CAD) risk factors of 67 CAD patients (male/female ratio 5) in Curacao. Compared with 57 controls, male CAD patients had higher cholesterol, triglycerides, LDL-cholesterol, apo-B and decreased HDL-cholesterol and HDL-cholesterol/cholesterol concentrations. Other CAD risk factors were increased fasting glucose and Hba concentration, decreased creatinine clearance, and increased prevalences of lipoprotein (a) concentration > 500 mg/l, renal disease, hyperhomcysteinaemia, diabetes mellitus type II (DM-II), positive CAD family history and cigarette smoking. Male CAD patients had higher plasma Ó-tocopherol. Compared with 29 female controls, female CAD patients had higher fasting plasma glucose with HbA concentrations, and prevalence of DM-II. Predicting factors for CAD development in the whole CAD group were DM-II, cigarette smoking, apo-E/E and apo-E/E Apo-E was associated with lower HDL-and higher LDL-cholesterol concentrations. There is a need for local studies on improvement of diabetic control, reference values of lipoprotein (a) and homocysteine concentrations, on apolipoprotein (a) phenotypes, causes of hyperhomocysteinaemia, and dietary influences on CAD development in subject who carry the apo-E allele.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Apolipoproteínas E
/
Doença das Coronárias
/
Lipídeos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
Antillas holandesas
/
Caribe ingles
Idioma:
En
Revista:
West Indian med. j
Assunto da revista:
MEDICINA
Ano de publicação:
1997
Tipo de documento:
Article
País de publicação:
Jamaica