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Serum cytokine profile in the subclinical form of visceral leishmaniasis
Gama, M. E. A; Costa, J. M. L; Pereira, J. C. R; Gomes, C. M. C; Corbett, C. E. P.
Afiliação
  • Gama, M. E. A; Universidade Federal do Maranhão. Departamento de Pediatria. São Luís. BR
  • Costa, J. M. L; Universidade Federal do Maranhão. Departamento de Patologia. São Luís. BR
  • Pereira, J. C. R; Instituto Dante Pazzanese. Laboratório de Epidemiologia e Estatística. São Paulo. BR
  • Gomes, C. M. C; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Corbett, C. E. P; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
Braz. j. med. biol. res ; 37(1): 129-136, Jan. 2004. ilus, tab
Article em En | LILACS | ID: lil-352110
Biblioteca responsável: BR1.1
ABSTRACT
The factors determining the development or not of visceral leishmaniasis (VL) have not been completely identified, but a Leishmania-specific cellular immune response seems to play a fundamental role in the final control of infection. Few studies are available regarding the production of cytokines in the subclinical form of VL, with only the production of IFN-g and TNF-a known. The aim of the present study was to identify immunological markers for the oligosymptomatic or subclinical form of VL. A prospective cohort study was conducted on 784 children aged 0 to 5 years from an endemic area in the State of Maranhão, Brazil, between January 1998 and December 2001. During 30 consecutive months of follow-up, 33 children developed the oligosymptomatic form of the disease and 12 the acute form. During the clinical manifestations, serum cytokine levels were determined in 27 oligosymptomatic children and in nine patients with the acute form using a quantitative sandwich enzyme immunoassay. In the subclinical form of VL, variable levels of IL-2 were detected in 52.3 percent of the children, IL-12 in 85.2 percent, IFN-g in 48.1 percent, IL-10 in 88.9 percent, and TNF-a in 100.0 percent, with the last two cytokines showing significantly lower levels than in the acute form. IL-4 was not detected in oligosymptomatic individuals. Multiple discriminant analysis used to determine the profile or combination of cytokines predominating in the subclinical form revealed both a Leishmania resistance (Th1) and susceptibility (Th2) profile. The detection of both Th1 and Th2 cytokine profiles explains the self-limited evolution accompanied by the discrete alterations observed for the subclinical form of VL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Citocinas / Leishmaniose Visceral Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant / Newborn Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2004 Tipo de documento: Article / Congress and conference País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Citocinas / Leishmaniose Visceral Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant / Newborn Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2004 Tipo de documento: Article / Congress and conference País de afiliação: Brasil País de publicação: Brasil