Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos

Cuevas M., Ada; Alvarez V., Verónica; Acosta B., Ana María; Altayó F., Marcela; Montero L., Joaquín; Rigotti R., Attilio

Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos / Mechanisms of hypo and hyper alphalipoproteinemia in Chilean adults

Cuevas M., Ada; Alvarez V., Verónica; Acosta B., Ana María; Altayó F., Marcela; Montero L., Joaquín; Rigotti R., Attilio.

Afiliação

Cuevas M., Ada; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Nutrición, Diabetes y Metabolismo. Santiago. CL
Alvarez V., Verónica; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Nutrición, Diabetes y Metabolismo. Santiago. CL
Acosta B., Ana María; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Nutrición, Diabetes y Metabolismo. Santiago. CL
Altayó F., Marcela; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Gastroenterología. Santiago. CL
Montero L., Joaquín; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Medicina Interna. Santiago. CL
Rigotti R., Attilio; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Gastroenterología. Santiago. CL

Rev. méd. Chile ; 132(4): 421-428, abr. 2004. ilus, tab, graf

Article em Es | LILACS | ID: lil-362906

Biblioteca responsável: CL12.1

ABSTRACT

ABSTRACT

Background:

High density lipoprotein (HDL) cholesterol is inversely associated to atherosclerotic cardiovascular risk. Disturbances in HDL cholesterol plasma leves are frecuent in the Chilean population, however the pathophysiological mechanisms are unknown.

Aim:

To evaluate the mechanisms involved in the hypo and hyper alfalipoproteinemias in Chilean subjects. Materials and

Methods:

Twenty three subjects with hyperalphalipoproteinemia and 12 with hypoalphalipoproteinemia, paired with control subjects (col-HDL between 35 and 55 mg/dl) were studied. We measured plasma lipids, subfractions and sizing of HDL particles and enzymatic activity of cholesteryl ester transfer protein (CETP), lecithin cholesterol acyltransferase (LCAT), lipoprotein lipase (LPL) and hepatic lipase (LH).

Results:

Subjects with hyperalphalipoproteinemia showed significantly higher levels of total HDL-cholesterol (70±2 vs 44±1 mg/dl), HDL 2 (30±3 vs 5±1 mg/dl), Apo A I (175±3 vs 146±4 mg/dl), lower HL activity (23,7±0,8 vs 32,4±1,8 mmol/h/l) and HDL particles of greater size, compared to their controls. Subjects with hypoalphalipoproteinemia, showed significantly lower levels of total HDL-cholesterol (26±1 vs 48±2 mg/dl), HDL 3 (21±1 vs 40±2 mg/dl), Apo A I (107±5 vs 145±7 mg/dl), lower LCAT activity (18,6±1,9 vs 26,2±1,6 nmol/h/ml) and smaller HDL particles, compared to their controls.

Conclusion:

Changes in hepatic lipase and lecithin cholesterol acyltransferase activities may explain the hyper and hypo alphalipoproteinemia respectively, in Chilean subjects.

Assuntos

Humanos; Masculino; Adulto; Feminino; Hiperlipoproteinemias; Hipolipoproteinemias; HDL-Colesterol; LDL-Colesterol; Chile/epidemiologia; Lipoproteínas; Lipoproteínas HDL; Lipoproteínas LDL

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Hiperlipoproteinemias / Hipolipoproteinemias Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Chile Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile

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