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Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations
Bracco Neto, Humberto; Colucci, Anete; Puccini, Rosana F; Farhat, Calil K.
Afiliação
  • Bracco Neto, Humberto; Federal University of São Paulo. Department of Pediatrics. São Paulo. BR
  • Colucci, Anete; Federal University of São Paulo. Department of Pediatrics. São Paulo. BR
  • Puccini, Rosana F; Federal University of São Paulo. Department of Pediatrics. São Paulo. BR
  • Farhat, Calil K; Federal University of São Paulo. Department of Pediatrics. São Paulo. BR
Braz. j. infect. dis ; 9(5): 363-373, Oct. 2005. tab, graf
Article em En | LILACS | ID: lil-419645
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

To evaluate the immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type b conjugate vaccine (PRP-T) in Brazilian infants. MATERIAL AND

METHODS:

A prospective and open clinical study, in which 110 infants were immunized with a three-dose primary vaccination regime at two, four and six months of age and with a single booster vaccination. Blood samples were drawn immediately before the first dose, one month after the third dose, at the time of the booster dose and one month after the booster to assess seropositivity and antibody geometric mean titers (GMTs) of antibodies for diphtheria, tetanus, hepatitis B, Haemophilus influenzae type b and for the three pertussis antigens Pertussis Toxin (PT), Filamentous Hemagglutinin (FHA) and Pertactin (PRN).

RESULTS:

Among the original 110 infants, 93 completed the study. Seropositivity was 100 percent for all seven involved antibodies, after the primary vaccination course. At the time of the booster dose, all antibodies (except diphtheria 33.7 percent and anti-PT 59 percent) were seropositive for more than 94 percent of subjects. After the booster, seropositivity increased to 100 percent for all antibodies. The GMT of these antibodies followed a similar pattern, with a strong increase after the primary course, followed by a second increase after the booster dose. At this time, GMT was2- to 7-fold higher than after the primary course, for all vaccine components.

CONCLUSIONS:

Concomitant administration of DTPa-HB and Hib vaccines elicited strong seroprotection for all the antigenic components. No interference with antibody response was evident. The vaccines provided high immunogenicity, following both the primary vaccinations and the booster dose.
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Toxoide Tetânico / Vacinas contra Hepatite B / Vacinas Anti-Haemophilus / Vacinas contra Difteria, Tétano e Coqueluche Acelular / Anticorpos Antibacterianos / Anticorpos Antivirais Tipo de estudo: Observational_studies Limite: Humans / Infant País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Toxoide Tetânico / Vacinas contra Hepatite B / Vacinas Anti-Haemophilus / Vacinas contra Difteria, Tétano e Coqueluche Acelular / Anticorpos Antibacterianos / Anticorpos Antivirais Tipo de estudo: Observational_studies Limite: Humans / Infant País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil