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Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
Sangiorgio, F; Sakate, M; Nogueira, R. M. B; Tostes, R. A.
Afiliação
  • Sangiorgio, F; São Paulo State University. School of Veterinary Medicine and Animal Husbrandy. Department of Small Animal Medical Clinic and Toxicology. Botucatu. BR
  • Sakate, M; São Paulo State University. School of Veterinary Medicine and Animal Husbrandy. Department of Small Animal Medical Clinic and Toxicology. Botucatu. BR
  • Nogueira, R. M. B; University of Western São Paulo. Department of Small Animal Medical Clinic. BR
  • Tostes, R. A; Maringá University Center. Maringá. BR
J. venom. anim. toxins incl. trop. dis ; 14(1): 82-99, 2008. ilus, graf
Article em En | LILACS | ID: lil-479341
Biblioteca responsável: BR33.1
ABSTRACT
The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Venenos de Crotalídeos / Cães Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Venenos de Crotalídeos / Cães Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil