Your browser doesn't support javascript.
loading
Kinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venom
Sangiorgio, F; Sakate, M; Nogueira, R. M. B; Araújo Júnior, J. P; Chavez-Olortegui, C.
Afiliação
  • Sangiorgio, F; São Paulo State University. School of Veterinary Medicine and Animal Husbrandy. Department of Small Animal Medical Clinic and Toxicology. Botucatu. BR
  • Sakate, M; São Paulo State University. School of Veterinary Medicine and Animal Husbrandy. Department of Small Animal Medical Clinic and Toxicology. Botucatu. BR
  • Nogueira, R. M. B; University of Western São Paulo. Department of Small Animal Medical Clinic. Presidente Prudente. BR
  • Araújo Júnior, J. P; UNESP. Botucatu Institute of Biosciences. Department of Microbiology and Immunology. Botucatu. BR
  • Chavez-Olortegui, C; Federal University of Minas Gerais. Institute of Biological Sciences. Department of Biochemistry and Immunology. Belo Horizonte. BR
J. venom. anim. toxins incl. trop. dis ; 14(1): 100-112, 2008. ilus, graf, tab
Article em En | LILACS | ID: lil-479342
Biblioteca responsável: BR33.1
ABSTRACT
This work evaluated the clinical and therapeutic aspects as well as serum levels of venom and antivenom IgG by enzyme-linked immunosorbent assay (ELISA) in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into four groups of seven animals each, Group I only venom; Group II, venom + 50 ml of anti-bothropic-crotalic serum (50mg) + fluid therapy; Group III, venom + 50 ml of anti-bothropic-crotalic serum + fluid therapy + urine alkalination; Group IV, 50 ml of anti-bothropic-crotalic serum. The lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and subcutaneously inoculated at the dose of 1mg/kg body weight. The dogs presented clinical signs of local pain, weakness, mandibular ptosis, mydriasis, emesis and salivation. The venom levels detected by ELISA ranged from 0 to 90ng/ml, according to the severity of the clinical signs. Serum antivenom ranged from 0 to 3ug/ml and was detected for up to 138h after treatment. ELISA results showed the effectiveness of the serum therapy for the venom neutralization.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Antivenenos / Venenos de Crotalídeos / Cães Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Antivenenos / Venenos de Crotalídeos / Cães Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil