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Relationship between Helicobacter pylori detection and an increased risk of infection in childhood
Venerando, R; Rasmussen, L T; Labio, R W de; Gatti, L L; Francisco, O; Viani, G A; Rivera, L M L; Payão, S L M.
Afiliação
  • Venerando, R; Sacred Heart University. Bauru. BR
  • Rasmussen, L T; Sacred Heart University. Bauru. BR
  • Labio, R W de; Marília Medical School. Department of Genetics Famema Blood Center. Marília. BR
  • Gatti, L L; Ourinhos Integrated College. Ourinhos. BR
  • Francisco, O; Ourinhos Integrated College. Ourinhos. BR
  • Viani, G A; Marília Medical School. Department of Radiotherapy and Oncology. Marília. BR
  • Rivera, L M L; Sacred Heart University. Bauru. BR
  • Payão, S L M; Sacred Heart University. Bauru. BR
J. venom. anim. toxins incl. trop. dis ; 18(4): 369-374, 2012. tab
Article em En | LILACS | ID: lil-658986
Biblioteca responsável: BR33.1
ABSTRACT
The risk of developing gastric cancer is believed to be related to differences among Helicobacter pylori strains and the inflammatory responses mediated by host genetic factors. H. pylori infection is acquired at an early age and in the absence of appropriate antibiotic therapy, it generally persists for life. Tp53 gene regulates the transcription of several cytokines and chemokines involved in innate immunity and its action may be influenced by the presence of different H. pylori strains. The present study aimed to detect H. pylori in pediatric patients, to access Tp53 polymorphism at codon 72 and to correlate such findings with age and histopathological results. Three hundred and forty-two patients were analyzed. DNA from their gastric biopsies was extracted and the detection of H. pylori was performed through polymerase chain reaction assays, urease test and histopathologic examination. Allelic discrimination of SNP rs1042522 (Tp53) was performed by real-time polymerase chain reaction. Our results suggest a possible relationship between the presence of H. pylori and chronic gastritis in children and young patients, and showed a significant association between ageing and positivity for H. pylori. It was verified that patients aged < 10 years were 1.3 times more likely to have infection by H. pylori when compared with those aged > 10 years. Finally, no association was found between Tp53 polymorphisms and the presence of H. pylori.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Reação em Cadeia da Polimerase / Helicobacter pylori / Infecções por Helicobacter Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2012 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Reação em Cadeia da Polimerase / Helicobacter pylori / Infecções por Helicobacter Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2012 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil