The Herpes simplex virus type 2 (HSV-2) gene ICP10PK has a wide neuroprotective spectrum through activation of survival signaling pathways
In. II International Congress on Neuroregeneration. Proceedings (selected papers). Rio de Janeiro, UFRJ, 2004. p.113-126, ilus, graf.
Monography
em En
| LILACS
| ID: lil-682600
Biblioteca responsável:
BR408.1
Localização: BR408.1; CD616.6, P963, 2004
ABSTRACT
This review discusses present understanding of the role of apoptosis and signaling cascades in neuronal pathogenesis and survival. It focuses on a herpes simplex virus type 2 (HSV-2) gene, known as ICP10PK, that prevents cell death/apoptosis in a wide spectrum of neurodegenerative conditions. Therapeutic implications for the development of HSV vectors that deliver ICP10PK and their use in the treatment/prevention of neurodegenerative disease are discussed.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Apoptose
/
Fármacos Neuroprotetores
/
Neurologia
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Congress and conference
/
Monography
País de publicação:
Brasil