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Esthesioneuroblastoma, Neuroendocrine Carcinoma, and Sinonasal Undifferentiated Carcinoma: Differentiation in Diagnosis and Treatment
Su, Shirley Y; Bell, Diana; Hanna, Ehab Y.
Afiliação
  • Su, Shirley Y; University of Texas. MD Anderson Cancer Center. Department of Head and Neck Surgery. Houston. US
  • Bell, Diana; University of Texas. MD Anderson Cancer Center. Department of Pathology. Houston. US
  • Hanna, Ehab Y; University of Texas. MD Anderson Cancer Center. Department of Head and Neck Surgery. Houston. US
Int. arch. otorhinolaryngol. (Impr.) ; 18(supl.2): 149-156, Apr-Jun/2014. graf
Article em En | LILACS | ID: lil-728763
Biblioteca responsável: BR66.1
ABSTRACT

Introduction:

Malignant sinonasal tumors comprise less than 1% of all neoplasms. A wide variety of tumors occurring primarily in this site can present with an undifferentiated or poorly differentiated morphology. Among them are esthesioneuroblastomas, sinonasal undifferentiated carcinomas, and neuroendocrine carcinomas.

Objectives:

We will discuss diagnostic strategies, recent advances in immunohistochemistry and molecular diagnosis, and treatment strategies. Data

Synthesis:

These lesions are diagnostically challenging, and up to 30% of sinonasal malignancies referred to the University of Texas MD Anderson Cancer Center are given a different diagnosis on review of pathology. Correct classification is vital, as these tumors are significantly different in biological behavior and response to treatment. The past decade has witnessed advances in diagnosis and therapeutic modalities leading to improvements in survival. However, the optimal treatment for esthesioneuroblastoma, sinonasal undifferentiated carcinoma, and neuroendocrine carcinoma remain debated. We discuss advances in immunohistochemistry and molecular diagnosis, diagnostic strategies, and treatment selection. Conclusions There are significant differences in prognosis and treatment for esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. Recent advances have the potential to improve oncologic outcomes but further investigation in needed...
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Nasais / Estesioneuroblastoma Olfatório / Carcinoma Neuroendócrino Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Int. arch. otorhinolaryngol. (Impr.) Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Nasais / Estesioneuroblastoma Olfatório / Carcinoma Neuroendócrino Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Int. arch. otorhinolaryngol. (Impr.) Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil