[Presence of inhibitors of activated partial thromboplastin time (TTPA). Clinical repercussion in obstetric patients]. / Presencia de inhibidores del tiempo tromboplastina parcial activada (TTPA). Repercusión clínica en pacientes obstétricas.
Ginecol Obstet Mex
; 60: 22-6, 1992 Jan.
Article
em Es
| MEDLINE
| ID: mdl-1555788
ABSTRACT
PIP: In a retrospective case control study of 96 obstetrical patients 48 cases had partial thromboplastin time (TTPA) with kaolin over 4 seconds compared with the test group. The control group of 48 women with normal TTPA were also studied. Age, socioeconomic status, weight, family and personal illness history were included. Habitual abortion,neonatal death, and hypertension were recorded. The average TTPA value was 53.6 +or- 7.87 seconds for the case group vs 38.8 =or- 4.9 for the controls which was not statistically significant. No statistical significance was found regarding age, start of menarche, nutritional and socioeconomic status, and blood group. The body weight of the case group was higher with 58.5 kg =or- 14.4 kg (a range of 43.4-81.4 kg). There were 7 cases of thrombophlebitis (14.5%) in the lower extremities in the case group and none in the controls. There were 7 cases of habitual abortion in the case group defined as 3 or more miscarriages before 20 weeks of gestation vs 2 cases in controls. There were 4 cases of neonatal deaths associated with premature delivery in the case groups and none in controls. Acute hypertensive disease associated with pregnancy totaled to 8 cases in the 1st group (16.6%) and 4 cases in controls (8.3%). In both groups there were 2 cases of fetal death. In the case group there was 1 case of chromosomopathy and in the control group 1 case of premature expulsion of placenta. The TTPAs test is used mostly for the initial phase of studying patients suspected of having lupus anticoagulant (LA). LA belongs to abnormalities characterized by the presence of antiphospholipid antibodies. It is often used for diagnosing initial stages of autoimmunity which can frequently occur in thrombotic process, fetal loss, intrauterine growth retardation, and increased hypertensive illness in pregnancy.
Palavras-chave
Abortion, Spontaneous; Americas; Antibodies; Autoimmune Response; Biology; Blood Coagulation Effects; Case Control Studies; Developing Countries; Diseases; Embolism; Hematological Effects; Hemic System; Hypertension; Immunity; Immunologic Factors; Latin America; Measurement; Mexico; North America; Physiology; Pregnancy Complications; Research Methodology; Retrospective Studies; Studies; Systemic Lupus Erythematosus; Testing; Thromboembolism; Thrombophlebitis; Vascular Diseases
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tempo de Tromboplastina Parcial
/
Pré-Eclâmpsia
/
Aborto Habitual
/
Mortalidade Infantil
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
Es
Revista:
Ginecol Obstet Mex
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
México