Ovulatory dysfunction during continuous administration of low-dose levonorgestrel by subdermal implants.
Fertil Steril
; 56(1): 27-31, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1906017
ABSTRACT
PIP: The study sought to examine the endocrinologic profile of regularly menstruating users of levonorgestrel subdermal implants. This observational, prospective, case-controlled, comparative study occurred at the Family Planning Clinic of PROFAMILIA in Santo Domingo, Dominican Republic. 31 subjects agreed to receive Norplant contraceptive implants between 13-77 months prior to this study and there were 12 nonhormonal contraceptors who also volunteered to participate. Follicle stimulating hormone, luteinizing hormone, estradiol (E2), and progesterone (P) were serially assayed for 1 menstrual cycle, and almost 1/2 of the cycles of norplant acceptors were anovulatory: the remainder (55%) had some form of dysfunction such as diminished gonadotropin surge, luteal phase insufficiency (low P levels and shortened luteal phase), and E2 profiles different from controls. Anovulation is clearly 1 of the main mechanisms of Norplant action, but even in presumptive ovulatory cycles, the dysfunctions described could have contributed to the high contraceptive effectiveness of Norplant.
Palavras-chave
Americas; Biology; Caribbean; Case Control Studies; Contraception; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--administraction and dosage; Contraceptive Agents--side effects; Contraceptive Implants--administraction and dosage; Contraceptive Methods--administraction and dosage; Contraceptive Mode Of Action; Developing Countries; Dominican Republic; Endocrine System--changes; Estradiol--analysis; Estrogens; Examinations And Diagnoses; Family Planning; Follicle Stimulating Hormone--analysis; Gonadotropins; Gonadotropins, Pituitary; Hormones; Laboratory Examinations And Diagnoses; Latin America; Levonorgestrel--administraction and dosage; Levonorgestrel--side effects; Luteinizing Hormone--analysis; North America; Ovulation; Physiology; Progestational Hormones; Progesterone--analysis; Prospective Studies; Reproduction; Research Methodology; Studies
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovulação
/
Anticoncepcionais Orais Combinados
/
Norgestrel
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
República Dominicana
País de publicação:
Estados Unidos