[Células T reguladoras en lupus eritematoso generalizado].
Gac Med Mex
; 155(1): 72-79, 2019.
Article
em Es
| MEDLINE
| ID: mdl-30799464
RESUMEN
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a loss of tolerance to self-antigens and synthesis of different autoantibodies, with the formation and deposition of immune complexes and damage to multiple organs. T regulatory cells (Tregs) play a crucial role in maintaining peripheral tolerance, controlling the state of activation of the immune system and limiting autoimmune responses. The study of the number and function of the different Treg cell subpopulations in SLE has been the subject of intense research. Depending on the analyzed Treg cell phenotype, the frequency of these cells has been reported to be reduced, increased or unaltered in patients with SLE. In addition, different groups have described that Treg cells suppressive function is reduced or unaffected in patients with SLE. Taken together, the reported data suggest that Treg cells play a relevant role in the pathogenesis of SLE and that these lymphocytes can be considered potential targets for the design of new therapeutic strategies for this condition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
/
Linfócitos T Reguladores
/
Lúpus Eritematoso Sistêmico
Limite:
Humans
Idioma:
Es
Revista:
Gac Med Mex
Ano de publicação:
2019
Tipo de documento:
Article
País de publicação:
México