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A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways.
de Almeida, Patricia D O; Dos Santos Barbosa Jobim, Gleyce; Dos Santos Ferreira, Caio César; Rocha Bernardes, Lucas; Dias, Rosane B; Schlaepfer Sales, Caroline B; Valverde, Ludmila de F; Rocha, Clarissa A G; Soares, Milena B P; Bezerra, Daniel P; de Carvalho da Silva, Fernando; Cardoso, Mariana Filomena do Carmo; Ferreira, Vitor Francisco; Brito, Larissa F; Pires de Sousa, Lirlândia; de Vasconcellos, Marne C; Lima, Emerson S.
Afiliação
  • de Almeida PDO; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
  • Dos Santos Barbosa Jobim G; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
  • Dos Santos Ferreira CC; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
  • Rocha Bernardes L; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
  • Dias RB; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
  • Schlaepfer Sales CB; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil; Department of Biomorphology, Institute of Health Sciences, Federal University of Bahia - UFBA, Salvador, Bahia, 40110-902, Brazil.
  • Valverde LF; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
  • Rocha CAG; Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
  • Soares MBP; Laboratory of Tissue Engineering and Immunopharmacology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
  • Bezerra DP; Laboratory of Tissue Engineering and Immunopharmacology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia, 40296-710, Brazil.
  • de Carvalho da Silva F; Laboratory of Carbohydrate and Nucleotide Synthesis, Department of Organic Chemistry, Federal Fluminense University - UFF, Niterói, Rio de Janeiro, 24020-141, Brazil.
  • Cardoso MFDC; Laboratory of Carbohydrate and Nucleotide Synthesis, Department of Organic Chemistry, Federal Fluminense University - UFF, Niterói, Rio de Janeiro, 24020-141, Brazil.
  • Ferreira VF; Laboratory of Carbohydrate and Nucleotide Synthesis, Department of Organic Chemistry, Federal Fluminense University - UFF, Niterói, Rio de Janeiro, 24020-141, Brazil.
  • Brito LF; Laboratory of Signaling in Inflammation, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
  • Pires de Sousa L; Laboratory of Signaling in Inflammation, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
  • de Vasconcellos MC; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil.
  • Lima ES; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Federal University of Amazonas - UFAM, Manaus, Amazonas, 69077-000, Brazil. Electronic address: eslima@ufam.edu.br.
Chem Biol Interact ; 343: 109444, 2021 Jul 01.
Article em En | MEDLINE | ID: mdl-33939975
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Espécies Reativas de Oxigênio / Apoptose / Sistema de Sinalização das MAP Quinases / Melanoma / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Espécies Reativas de Oxigênio / Apoptose / Sistema de Sinalização das MAP Quinases / Melanoma / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda