Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux.

Yang, Dong-Lin; Zhang, Ya-Jun; He, Liu-Jun; Hu, Chun-Sheng; Gao, Li-Xia; Huang, Jiu-Hong; Tang, Yan; Luo, Jie; Tang, Dian-Yong; Chen, Zhong-Zhu

Yang, Dong-Lin; Zhang, Ya-Jun; He, Liu-Jun; Hu, Chun-Sheng; Gao, Li-Xia; Huang, Jiu-Hong; Tang, Yan; Luo, Jie; Tang, Dian-Yong; Chen, Zhong-Zhu.

Afiliação

Yang DL; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China. dlyang@cwu.edu.cn.
Zhang YJ; College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China. dlyang@cwu.edu.cn.
He LJ; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Hu CS; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Gao LX; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Huang JH; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Tang Y; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Luo J; College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China.
Tang DY; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Chen ZZ; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China.

Biol Res ; 54(1): 27, 2021 Sep 06.

Article em En | MEDLINE | ID: mdl-34488902

Assuntos

Autofagia; Neoplasias da Próstata; Apoptose; Linhagem Celular Tumoral; Humanos; Masculino; Neoplasias da Próstata/tratamento farmacológico; Espécies Reativas de Oxigênio; Triterpenos

Palavras-chave

Apoptosis; Autophagic flux; CaP; Cisplatin; ER stress; T-96

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Autofagia Limite: Humans / Male Idioma: En Revista: Biol Res Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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