Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells.

Faria, Alessandra V S; Yu, Bingting; Mommersteeg, Michiel; de Souza-Oliveira, Patrícia F; Andrade, Sheila S; Spaander, Manon C W; de Maat, Moniek P M; Peppelenbosch, Maikel P; Ferreira-Halder, Carmen V; Fuhler, Gwenny M

Faria, Alessandra V S; Yu, Bingting; Mommersteeg, Michiel; de Souza-Oliveira, Patrícia F; Andrade, Sheila S; Spaander, Manon C W; de Maat, Moniek P M; Peppelenbosch, Maikel P; Ferreira-Halder, Carmen V; Fuhler, Gwenny M.

Afiliação

Faria AVS; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands; Department of Biochemistry and Tissue Biology, University of Campinas, UNICAMP, Campinas, SP 13083-862, Brazil.
Yu B; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands.
Mommersteeg M; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands.
de Souza-Oliveira PF; Department of Biochemistry and Tissue Biology, University of Campinas, UNICAMP, Campinas, SP 13083-862, Brazil.
Andrade SS; PlateInnove Biotechnology, 13414-018 Piracicaba, SP, Brazil.
Spaander MCW; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands.
de Maat MPM; Department of Hematology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands.
Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands.
Ferreira-Halder CV; Department of Biochemistry and Tissue Biology, University of Campinas, UNICAMP, Campinas, SP 13083-862, Brazil. Electronic address: carmenv@unicamp.br.
Fuhler GM; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA Rotterdam, the Netherlands. Electronic address: g.fuhler@erasmusmc.nl.

Biochim Biophys Acta Mol Basis Dis ; 1868(1): 166280, 2022 01 01.

Article em En | MEDLINE | ID: mdl-34610471

Assuntos

Plaquetas/metabolismo; Carcinogênese/genética; Neoplasias Gastrointestinais/genética; Proteínas Tirosina Fosfatases/genética; Proteínas Proto-Oncogênicas/genética; Plaquetas/patologia; Linhagem Celular Tumoral; Proliferação de Células/genética; Técnicas de Cocultura; Feminino; Neoplasias Gastrointestinais/patologia; Regulação Neoplásica da Expressão Gênica/genética; Humanos; Masculino; Peso Molecular; Metástase Neoplásica; Transdução de Sinais/genética; Microambiente Tumoral/genética

Palavras-chave

ACP1; Gastrointestinal cancer; LMWPTP; Platelets; Tumor microenvironment; Tyrosine phosphatases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Proteínas Proto-Oncogênicas / Proteínas Tirosina Fosfatases / Carcinogênese / Neoplasias Gastrointestinais Limite: Female / Humans / Male Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

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