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Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQß1.
Valencia, Ana; Vergara, Candelaria; Thio, Chloe L; Vince, Nicolas; Douillard, Venceslas; Grifoni, Alba; Cox, Andrea L; Johnson, Eric O; Kral, Alex H; Goedert, James J; Mangia, Alessandra; Piazzolla, Valeria; Mehta, Shruti H; Kirk, Gregory D; Kim, Arthur Y; Lauer, Georg M; Chung, Raymond T; Price, Jennifer C; Khakoo, Salim I; Alric, Laurent; Cramp, Matthew E; Donfield, Sharyne M; Edlin, Brian R; Busch, Michael P; Alexander, Graeme; Rosen, Hugo R; Murphy, Edward L; Wojcik, Genevieve L; Carrington, Mary; Gourraud, Pierre-Antoine; Sette, Alessandro; Thomas, David L; Duggal, Priya.
Afiliação
  • Valencia A; Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA; Universidad Pontificia Bolivariana, Medellín, Antioquia 050031, Colombia.
  • Vergara C; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Thio CL; Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
  • Vince N; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes 44000, France.
  • Douillard V; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes 44000, France.
  • Grifoni A; Center for infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
  • Cox AL; Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
  • Johnson EO; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC 27709, USA.
  • Kral AH; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC 27709, USA.
  • Goedert JJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Mangia A; Liver Unit, Medical Sciences Department, Fondazione "Casa Sollievo della Sofferenza" IRCCS, 71013 San Giovanni Rotondo, Italy.
  • Piazzolla V; Liver Unit, Medical Sciences Department, Fondazione "Casa Sollievo della Sofferenza" IRCCS, 71013 San Giovanni Rotondo, Italy.
  • Mehta SH; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Kirk GD; Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Kim AY; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Lauer GM; Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Chung RT; Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Price JC; Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Francisco, CA 94143, USA.
  • Khakoo SI; University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
  • Alric L; Internal Medicine-Department of Digestive Diseases, Rangueil Hospital, Toulouse University, 1, 31400 Toulouse, France.
  • Cramp ME; South West Liver Unit, Plymouth PL6 8DH, UK.
  • Donfield SM; Rho, Inc., Durham, NC 27713, USA.
  • Edlin BR; SUNY Downstate College of Medicine, Brooklyn, NY 11203, USA.
  • Busch MP; University of California San Francisco and Vitalant Research Institute, San Francisco, CA 94118, USA.
  • Alexander G; UCL Institute for Liver and Digestive Health, The Royal Free Hospital, Pond St, Hampstead, London NW3 2QG, UK.
  • Rosen HR; University of Colorado, Aurora, CO 80045, USA.
  • Murphy EL; University of California San Francisco and Vitalant Research Institute, San Francisco, CA 94118, USA.
  • Wojcik GL; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Carrington M; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Ragon Institute of MGH, MIT and Harvard, Cambrid
  • Gourraud PA; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes 44000, France.
  • Sette A; Center for infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.
  • Thomas DL; Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
  • Duggal P; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: pduggal@jhu.edu.
Am J Hum Genet ; 109(2): 299-310, 2022 02 03.
Article em En | MEDLINE | ID: mdl-35090584
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Hepacivirus / Polimorfismo de Nucleotídeo Único / Interações Hospedeiro-Patógeno / Cadeias beta de HLA-DQ Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Am J Hum Genet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Hepacivirus / Polimorfismo de Nucleotídeo Único / Interações Hospedeiro-Patógeno / Cadeias beta de HLA-DQ Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Am J Hum Genet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos