Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-&#954;B pathway in CUMS mice.

Xiao, Xi; Zhang, Hui; Ning, Wen; Yang, Zhuo; Wang, Yue; Zhang, Tao

Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice.

Xiao, Xi; Zhang, Hui; Ning, Wen; Yang, Zhuo; Wang, Yue; Zhang, Tao.

Afiliação

Xiao X; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, 300071 Tianjin, PR China; Tianjin International Joint Research Center for Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, 300072 Tianjin, PR
Zhang H; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, 300071 Tianjin, PR China.
Ning W; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, 300071 Tianjin, PR China.
Yang Z; School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, PR China.
Wang Y; School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, PR China. Electronic address: Wangyue@nankai.edu.cn.
Zhang T; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, 300071 Tianjin, PR China. Electronic address: zhangtao@nankai.edu.cn.

Exp Neurol ; 353: 114060, 2022 07.

Article em En | MEDLINE | ID: mdl-35367454

Assuntos

Proteínas Relacionadas à Folistatina/metabolismo; NF-kappa B; Animais; Depressão/metabolismo; Modelos Animais de Doenças; Proteínas Relacionadas à Folistatina/genética; Hipocampo/metabolismo; Camundongos; Microglia/metabolismo; Fator 88 de Diferenciação Mieloide; NF-kappa B/metabolismo; Estresse Psicológico/tratamento farmacológico; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Chronic unpredictable mild stress; Depressive symptoms; FSTL1; Microglia; Neuro-inflammation; TLR4/MyD88/NF-κB pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Proteínas Relacionadas à Folistatina Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Exp Neurol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Porto Rico País de publicação: Estados Unidos

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