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Açai pulp improves cognition and insulin sensitivity in obese mice.
Medina Dos Santos, Nathalia; Batista, Ângela Giovana; Padilha Mendonça, Monique Culturato; Figueiredo Angolini, Célio Fernando; Grimaldi, Renato; Pastore, Glaucia Maria; Sartori, César Renato; Alice da Cruz-Höfling, Maria; Maróstica Júnior, Mário Roberto.
Afiliação
  • Medina Dos Santos N; Department of Food and Nutrition, School of Food Engineering, University of Campinas, Campinas, Brazil.
  • Batista ÂG; Institute of Life Sciences, Federal University of Juiz de Fora, Governador Valadares, Brazil.
  • Padilha Mendonça MC; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Figueiredo Angolini CF; Department of Food Science, School of Food Engineering, University of Campinas, Brazil.
  • Grimaldi R; Department of Food Technology, Faculty of Food Engineering, University of Campinas, Brazil.
  • Pastore GM; Department of Food Science, School of Food Engineering, University of Campinas, Brazil.
  • Sartori CR; Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Alice da Cruz-Höfling M; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Maróstica Júnior MR; Department of Food and Nutrition, School of Food Engineering, University of Campinas, Campinas, Brazil.
Nutr Neurosci ; 27(1): 55-65, 2024 Jan.
Article em En | MEDLINE | ID: mdl-36625400
ABSTRACT
SCOPE Obesity and insulin resistance constitute risk factors for the development of tauopathies and other neurodegenerative diseases. (Poly)phenol compounds are under study for its role in protecting effects against neural injuries and degeneration. Here, we investigated the effect of Amazonian açai pulp (AP) intake in the prevention of memory and cognitive impairment resulting from a high-fat diet intake in mice. METHODS AND

RESULTS:

Obesity and insulin resistance was induced with a high-fat diet and supplemented with 2% AP to investigate peripheral insulin resistance, recognition memory and tau protein stability via AKT/GSK3-ß signaling pathway. The consumption of AP for 70 days improved peripheral insulin sensitivity and phosphorylation of AKT/GSK3-ß in mice hippocampi. The animals fed high-fat diets supplemented with AP showed better performance in the novel object recognition test (NOR) in comparison to the H group. Catalase activity and reduced glutathione (GSH) values were improved in the treated mice.

CONCLUSIONS:

These results suggest that the supplementation of AP can attenuate the effects of high-fat diet consumption in peripheral insulin resistance and improve cognitive behavior.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido