Current state of molecular and metabolic strategies for the improvement of L-asparaginase expression in heterologous systems.

Lefin, Nicolás; Miranda, Javiera; Beltrán, Jorge F; Belén, Lisandra Herrera; Effer, Brian; Pessoa, Adalberto; Farias, Jorge G; Zamorano, Mauricio

Lefin, Nicolás; Miranda, Javiera; Beltrán, Jorge F; Belén, Lisandra Herrera; Effer, Brian; Pessoa, Adalberto; Farias, Jorge G; Zamorano, Mauricio.

Afiliação

Lefin N; Department of Chemical Engineering, Science and Engineering Faculty, Universidad de La Frontera, Temuco, Chile.
Miranda J; Department of Chemical Engineering, Science and Engineering Faculty, Universidad de La Frontera, Temuco, Chile.
Beltrán JF; Department of Chemical Engineering, Science and Engineering Faculty, Universidad de La Frontera, Temuco, Chile.
Belén LH; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Santiago, Chile.
Effer B; Center of Excellence in Translational Medicine and Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, Chile.
Pessoa A; Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Farias JG; Department of Chemical Engineering, Science and Engineering Faculty, Universidad de La Frontera, Temuco, Chile.
Zamorano M; Department of Chemical Engineering, Science and Engineering Faculty, Universidad de La Frontera, Temuco, Chile.

Front Pharmacol ; 14: 1208277, 2023.

Article em En | MEDLINE | ID: mdl-37426818

Palavras-chave

L-asparaginase; heterologous expression system; industrial bioprocessing; molecular strategies; rational design

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça

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