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A new role for resveratrol: Protection of enamel against erosion.
Reis, Fernanda Navas; Pelá, Vinicius Taioqui; Câmara, João Victor Frazão; Ventura, Talita Mendes Oliveira; Rodrigues, Chelsea Maria Vilas Boas Feitosa; Lima, Karen Pavan de; Buzalaf, Marília Afonso Rabelo.
Afiliação
  • Reis FN; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil.
  • Pelá VT; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil.
  • Câmara JVF; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil.
  • Ventura TMO; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil.
  • Rodrigues CMVBF; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil.
  • Lima KP; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil.
  • Buzalaf MAR; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil. Electronic address: mbuzalaf@fob.usp.br.
J Dent ; 141: 104810, 2024 02.
Article em En | MEDLINE | ID: mdl-38110112
ABSTRACT

OBJECTIVE:

The aim of this study was to determine the effect of different concentrations of resveratrol in protecting enamel against initial dental erosion in vitro.

METHODS:

Ninety bovine enamel samples (4 × 4 mm) were divided into six groups Phosphate buffered saline (negative control; PBS), Commercial solution (Elmex Erosion Protection™; positive control) and resveratrol at 4 different concentrations (1, 10, 100 or 400 µg/mL). Initially, the samples were incubated in saliva for the formation of the acquired pellicle (250 µL, 1 h, 37 °C, 250 rpm). Afterward, the samples were incubated in the respective treatments (250 µL, 1 min, 37 °C, 250 rpm) and then reincubated in saliva (250 µL, 1 h, 37 °C, 250 rpm). Finally, the samples were subjected to an erosive challenge by incubating in 1 % citric acid (1 mL, pH 3.5, 1 min, 25 °C, 250 rpm). The percentage surface microhardness change (% SMC) was assessed using a microhardness tester. Data were analyzed by Kruskal-Wallis and Dunn's tests (p < 0.05).

RESULTS:

The treatments with Elmex™ and resveratrol (1, 10 and 100 µg/mL) significantly protected enamel compared to the negative control, without significant differences among them. However, the group treated with the highest resveratrol concentration (400 µg/mL) did not show a significant difference from the negative control.

CONCLUSIONS:

Resveratrol at concentrations ranging from 1 to 100 µg/ml was effective in preventing loss of enamel surface microhardness. CLINICAL

SIGNIFICANCE:

This result suggests a potential new direction for the development of dental products based on resveratrol for the prevention of dental erosion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Erosão Dentária Limite: Animals Idioma: En Revista: J Dent Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Erosão Dentária Limite: Animals Idioma: En Revista: J Dent Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido