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Effect of Propranolol on Motor Cortex Excitability in Essential Tremor: An Exploratory Study.
Miguel-Puga, Adán; Villafuerte, Gabriel; Treviño, Mario; Ortega-Robles, Emmanuel; Arias-Carrión, Oscar.
Afiliação
  • Miguel-Puga A; Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González. Ciudad de México, 14080 México, MX.
  • Villafuerte G; Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González. Ciudad de México, 14080 México, MX.
  • Treviño M; Laboratorio de Plasticidad Cortical y Aprendizaje Perceptual, Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, 44130 México, MX.
  • Ortega-Robles E; Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González. Ciudad de México, 14080 México, MX.
  • Arias-Carrión O; Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González. Ciudad de México, 14080 México, MX.
Tremor Other Hyperkinet Mov (N Y) ; 14: 1, 2024.
Article em En | MEDLINE | ID: mdl-38189055
ABSTRACT

Background:

Essential tremor, the world's most prevalent movement disorder, lacks a clear understanding of its pathophysiology. Propranolol, a non-specific beta-blocker capable of crossing the blood-brain barrier, is a primary choice for essential tremor treatment. While its tremor-reducing effects are generally attributed to peripheral actions, various uses hint at central adrenergic effects. Nevertheless, propranolol's precise impact on the central nervous system in essential tremor subjects remains unexplored.

Methods:

In this study, we employed transcranial magnetic stimulation to assess the influence of propranolol on the excitability of the primary motor cortex (M1) in patients with essential tremor, compared to an age- and sex-matched control group. Cortical excitability parameters were measured following placebo and propranolol administration, encompassing resting and active motor thresholds, motor evoked potential characteristics, cortical silent period, and the input/output curve.

Results:

Distinct effects were observed across the two cortical hemispheres. Essential tremor patients displayed inhibition of the left M1 cortex and heightened excitability in the right M1 cortex four hours after propranolol administration, but not following placebo.

Conclusions:

These findings suggest potential differential noradrenergic excitatory and inhibitory modulation. However, comprehensive understanding necessitates further investigations, including left-handed participants and more diverse essential tremor subpopulations. This study underscores the need for continued exploration to unravel propranolol's complex effects on motor cortex excitability in essential tremor.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tremor Essencial / Córtex Motor Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Tremor Other Hyperkinet Mov (N Y) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tremor Essencial / Córtex Motor Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Tremor Other Hyperkinet Mov (N Y) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido