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Factors Associated with Overt Stroke in Children and Adolescents with Sickle Cell Disease: A Retrospective Cohort Study.
de Oliveira Taques, Wolney; Bett, Gabriele Curvo; de Moraes, Bárbara Lucia Barbosa; Medeiros, Iasmin; Fontes, Cor Jesus Fernandes; Godinho de Oliveira, Ruberlei.
Afiliação
  • de Oliveira Taques W; Júlio Müller University Hospital/EBSERH, Teaching and Research Management, Federal University of Mato Grosso - UFMT, Cuiabá, Brazil.
  • Bett GC; Medicine Course, Várzea Grande University Center (UNIVAG), Várzea Grande, Brazil.
  • de Moraes BLB; Hematology Outpatient Clinic of MT-Hemocentro, State Health Department of MT - Mato Grosso, Cuiabá, Brazil.
  • Medeiros I; Medicine Course, Várzea Grande University Center (UNIVAG), Várzea Grande, Brazil.
  • Fontes CJF; Medicine Course, Várzea Grande University Center (UNIVAG), Várzea Grande, Brazil.
  • Godinho de Oliveira R; Medicine Course, Várzea Grande University Center (UNIVAG), Várzea Grande, Brazil.
Hemoglobin ; 48(1): 39-46, 2024 Jan.
Article em En | MEDLINE | ID: mdl-38263710
ABSTRACT
Sickle cell disease (SCD) is associated with a high occurrence of complications due to vaso-occlusive phenomenon such as stroke. This retrospective cohort study aimed to examine the clinical and laboratory characteristics of 120 children and adolescents with SCD and analyze the factors associated with overt stroke incidence. All relevant data were obtained from patient medical records. Survival analysis was used to compare the demographic, clinical, and laboratory characteristics between patients with and those without overt stroke. The patients were 52.5% female with a mean (SD) age of 11.2 (4.3) years. The incidence of overt stroke in this cohort was nine out of 956.7 patient-years, resulting in an incidence density of 0.94 cases/100 patient-years. Reports of greater than or equal to two previous attacks of dactylitis and greater than or equal to three episodes of acute chest syndrome (ACS)/pneumonia were associated with overt stroke and an increase in reticulocyte count and red blood cell distribution width (RDW). In conclusion, a history of a high number of dactylitis, ACS/pneumonia, increased RDW, and reticulocytosis was associated with overt stroke occurrence in children and adolescents with SCD. Future studies with a higher stroke incidence in the evaluated sample are necessary to confirm this hypothesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Acidente Vascular Cerebral / Síndrome Torácica Aguda / Anemia Falciforme Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hemoglobin Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Acidente Vascular Cerebral / Síndrome Torácica Aguda / Anemia Falciforme Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hemoglobin Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido