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Clinical characteristics, diagnosis, treatment and outcomes of patients living with HIV and co-infected with tuberculosis and histoplasmosis: a 5-y retrospective case series.
Castellanos Reynosa, María Eugenia; Caal, Maria Eugenia; Mercado, Danicela; Medina, Narda; Pérez, Juan Carlos; Emeto, Theophilus I; Arathoon, Eduardo.
Afiliação
  • Castellanos Reynosa ME; Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
  • Caal ME; Asociación de Salud Integral, Guatemala City, Guatemala.
  • Mercado D; Clínica Familiar Luis Ángel García, Hospital General San Juan de Dios, Guatemala City, Guatemala.
  • Medina N; Asociación de Salud Integral, Guatemala City, Guatemala.
  • Pérez JC; Asociación de Salud Integral, Guatemala City, Guatemala.
  • Emeto TI; Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
  • Arathoon E; Asociación de Salud Integral, Guatemala City, Guatemala.
Trans R Soc Trop Med Hyg ; 118(6): 391-398, 2024 Jun 04.
Article em En | MEDLINE | ID: mdl-38279781
ABSTRACT

BACKGROUND:

In Latin America, tuberculosis (TB) and histoplasmosis are two of the most frequent opportunistic infections affecting people living with human immunodeficiency virus (HIV). However, there are limited data on the clinical characteristics and outcomes of patients with concurrent TB and histoplasmosis infections.

METHODS:

This was a retrospective observational study to describe the clinical, epidemiological and laboratory characteristics and outcomes of 21 patients living with HIV (PLHIV) who were diagnosed with concurrent histoplasmosis and TB between 2017 and 2021 in Guatemala City, Guatemala.

RESULTS:

Most patients were male and were newly diagnosed with HIV. All patients had advanced HIV disease (AHD). They presented with a median CD4 count of 20 cells/µl. The most common symptoms reported by the patients were fever, weight loss, cough and diarrhoea. Twelve patients died within 6 months of baseline evaluation, for a mortality rate of 57.1%.

CONCLUSIONS:

PLHIV with concurrent TB and histoplasmosis infections are characterised by AHD, predominantly presenting with disseminated forms of these infections and with unspecific symptoms and signs. This evidence calls for early HIV and opportunistic infection screening and insights into the challenges and opportunities for the efficient diagnostic and therapeutic management of patients with AHD with concurrent histoplasmosis and TB infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Infecções por HIV / Infecções Oportunistas Relacionadas com a AIDS / Coinfecção / Histoplasmose Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America central / Guatemala Idioma: En Revista: Trans R Soc Trop Med Hyg Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Infecções por HIV / Infecções Oportunistas Relacionadas com a AIDS / Coinfecção / Histoplasmose Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America central / Guatemala Idioma: En Revista: Trans R Soc Trop Med Hyg Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido