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Embryo development is impaired by sperm mitochondrial-derived ROS.
Mateo-Otero, Yentel; Llavanera, Marc; Torres-Garrido, Marc; Yeste, Marc.
Afiliação
  • Mateo-Otero Y; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain. yentel.mateo@udg.edu.
  • Llavanera M; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES- 17003, Spain. yentel.mateo@udg.edu.
  • Torres-Garrido M; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain.
  • Yeste M; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES- 17003, Spain.
Biol Res ; 57(1): 5, 2024 Jan 30.
Article em En | MEDLINE | ID: mdl-38287386
ABSTRACT

BACKGROUND:

Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development.

RESULTS:

We first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation.

CONCLUSION:

Collectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sêmen / Mitocôndrias Limite: Humans / Male Idioma: En Revista: Biol Res Assunto da revista: BIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sêmen / Mitocôndrias Limite: Humans / Male Idioma: En Revista: Biol Res Assunto da revista: BIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Reino Unido