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Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio and Their Relationship with Nutritional Status and Quality of Life of Hospitalized Women with Breast Cancer.
Silva, Roberto Júnio Gomes; Grippa, Wesley Rocha; Pessanha, Raphael Manhães; Enriquez-Martinez, Oscar Geovanny; Neto, Luiz Cláudio Barreto Silva; Lopes-Júnior, Luís Carlos.
Afiliação
  • Silva RJG; Graduate Program in Nutrition and Health at the Federal University of Espírito Santo (UFES), Vitoria, ES, Brazil.
  • Grippa WR; Graduate Program in Public Health at the Federal University of Espírito Santo (UFES), Vitoria, ES, Brazil.
  • Pessanha RM; Graduate Program in Public Health at the Federal University of Espírito Santo (UFES), Vitoria, ES, Brazil.
  • Enriquez-Martinez OG; Graduate Program in Public Health at the Federal University of Espírito Santo (UFES), Vitoria, ES, Brazil.
  • Neto LCBS; Graduate Program in Nutrition and Health at the Federal University of Espírito Santo (UFES), Vitoria, ES, Brazil.
  • Lopes-Júnior LC; Graduate Program in Nutrition and Health at the Federal University of Espírito Santo (UFES), Vitoria, ES, Brazil.
Nutr Cancer ; 76(3): 296-304, 2024.
Article em En | MEDLINE | ID: mdl-38287698
ABSTRACT
Blood cell biomarkers, such as the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR), have been recently used as prognostic markers in tumors. In this study, we investigated the association between NLR and PLR with sociodemographic, clinical, anthropometric, and quality of life factors of hospitalized women with non-metastatic breast cancer. A cross-sectional observational study was conducted at a reference center for oncological treatment in Southeast Brazil. Female participants aged over 18 years, with a histopathological diagnosis of stage I, II or III breast cancer, in any phase of antineoplastic treatment, were included. Our study revealed a high risk for participants, with high mean values of NLR and PLR, indicating low antitumor activity and worse prognosis. The binary logistic regression model showed that there was a significant association of the NLR marker and marital status (OR = 3.1; 95%CI = 1.06-8.57; p = 0.03) and, in relation to PLR, a trend was shown for a higher chance in women of black ethnicity to have increased PLR compared to white women (OR = 4.13; 95%CI = 0.96-17.70; p = 0.05). However, the inflammatory markers (NLR and PLR) did not show any significant association with nutritional factors. NLR and PLR are inflammatory biomarkers that can be easily obtained and measured in clinical practice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neutrófilos Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Nutr Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neutrófilos Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Nutr Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos