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Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation.
Diaz, Ana Claudia Marques Barbosa; Witkin, Steven Sol; Almeida Neto, Cesar de; Mendrone Junior, Alfredo; Rocha, Vanderson; Costa, Silvia Figueiredo; Ramos, Jessica Fernandes; Mendes-Correa, Maria Cassia.
Afiliação
  • Diaz ACMB; Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, São Paulo, Brazil.
  • Witkin SS; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Investigação Médica em Virologia (LIM-52), São Paulo, São Paulo, Brazil.
  • Almeida Neto C; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Investigação Médica em Virologia (LIM-52), São Paulo, São Paulo, Brazil.
  • Mendrone Junior A; Weill Cornel Medicine, Department of Obstetrics and Gynecology New York, New York, USA.
  • Rocha V; Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Costa SF; Universidade de São Paulo, Faculdade de Medicina, Disciplina de Ciências Médicas, São Paulo, São Paulo, Brazil.
  • Ramos JF; Fundação Pró-Sangue, Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Mendes-Correa MC; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Hematologia, Laboratório de Investigação Médica em Patogênese e Terapia Dirigida em Onco-Imuno-Hematologia (LIM-31), São Paulo, São Paulo, Brazil.
Rev Inst Med Trop Sao Paulo ; 66: e11, 2024.
Article em En | MEDLINE | ID: mdl-38324877
ABSTRACT
Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality among hematopoietic stem cell transplant (HCT) recipients. In Brazil, its occurrence in HCT recipients remains undetermined. We now report on HCV prevalence in HCT recipients and its clinical consequences. The medical records of all HCT recipients seen at Hospital das Clinicas, Sao Paulo University Medical School, from January 2010 to January 2020 were reviewed to determine HCV serostatus. A retrospective analysis of medical charts was undertaken on all seropositive cases to determine HCV genotype, presence of liver fibrosis, co-infections with other viruses, previous treatments, and clinical evolution of liver pathology after HCT. Of the 1,293 HCT recipients included in the study, seven (0.54%) were HCV antibody-positive and five (0.39%) were also viremic for HCV-RNA. Four of these individuals had moderate to severe liver fibrosis (METAVIR F2/F3) and one was cirrhotic. Two of the viremic patients developed acute liver dysfunction following transplantation. All patients had their acute episode of liver dysfunction resolved with no further complications. Four of the viremic patients were treated for HCV infection with direct acting agents (DAA). Information regarding HCV treatment was lacking for one of the viremic HCV patients due to loss of follow up. Sustained anti-virologic responses were observed in three cases after the use of DAA. The detection of HCV in hematological adults undergoing HCT and its successful treatment with DAA highlight the necessity of testing for HCV both prior to and following transplantation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Transplante de Células-Tronco Hematopoéticas / Hepatite C Crônica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Inst Med Trop Sao Paulo Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Transplante de Células-Tronco Hematopoéticas / Hepatite C Crônica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Inst Med Trop Sao Paulo Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil