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Chrysin bonded to ß-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice.
Okoh, Victor Ifeanyi; Campos, Hericles Mesquita; Yasmin de Oliveira Ferreira, Pâmela; Pereira, Robbert Mota; Souza Silva, Yohanny; Arruda, Evilanna Lima; Pagliarani, Barbara; de Almeida Ribeiro Oliveira, Gerlon; Lião, Luciano Morais; Franco Dos Santos, Gabriel; Vaz, Boniek Gontijo; Sabino, José Ricardo; Alcantara Dos Santos, Fernanda Cristina; Costa, Elson Alves; Tarozzi, Andrea; Menegatti, Ricardo; Ghedini, Paulo César.
Afiliação
  • Okoh VI; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Campos HM; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Yasmin de Oliveira Ferreira P; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Pereira RM; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Souza Silva Y; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Arruda EL; Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil.
  • Pagliarani B; Department for Life Quality Studies, Alma Mater Studiorum - University of Bologna, Rimini, Italy.
  • de Almeida Ribeiro Oliveira G; Institute of Chemistry, Federal University of Goias, Goiania, GO, Brazil.
  • Lião LM; Institute of Chemistry, Federal University of Goias, Goiania, GO, Brazil.
  • Franco Dos Santos G; Institute of Chemistry, Federal University of Goias, Goiania, GO, Brazil.
  • Vaz BG; Institute of Chemistry, Federal University of Goias, Goiania, GO, Brazil.
  • Sabino JR; Institute of Physics, Federal University of Goias, Goiania, GO, Brazil.
  • Alcantara Dos Santos FC; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Costa EA; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
  • Tarozzi A; Department for Life Quality Studies, Alma Mater Studiorum - University of Bologna, Rimini, Italy.
  • Menegatti R; Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil.
  • Ghedini PC; Institute of Biological Sciences, Federal University of Goias, Goiania, GO, Brazil.
J Pharm Pharmacol ; 76(4): 368-380, 2024 Apr 03.
Article em En | MEDLINE | ID: mdl-38330395
ABSTRACT

OBJECTIVES:

To evaluate whether the glycosylation of chrysin (CHR) enhances its protective effects against aluminum-induced neurotoxicity.

METHODS:

To compare the antioxidant, anticholinesterase, and behavioral effects of CHR with its glycosylated form (CHR bonded to ß-d-glucose tetraacetate, denoted as LQFM280), we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (aluminum-induced neurotoxicity in Swiss mice) models. KEY

FINDINGS:

LQFM280 demonstrated higher antioxidant activity than CHR in both models. Specifically, LQFM280 exhibited the ability to exert antioxidant effects in the cytoplasm of SH-SY5Y cells, indicating its competence in traversing neuronal membranes. Remarkably, LQFM280 proved more effective than CHR in recovering memory loss and counteracting neuronal death in the aluminum chloride mice model, suggesting its increased bioavailability at the brain level.

CONCLUSIONS:

The glycosylation of CHR with ß-d-glucose tetraacetate amplifies its neuroprotective effects, positioning LQFM280 as a promising lead compound for safeguarding against neurodegenerative processes involving oxidative stress.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Fármacos Neuroprotetores / Síndromes Neurotóxicas / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Fármacos Neuroprotetores / Síndromes Neurotóxicas / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido