Your browser doesn't support javascript.
loading
Dynamic clade transitions and the influence of vaccine rollout on the spatiotemporal circulation of SARS-CoV-2 variants in São Paulo, Brazil.
Banho, Cecília Artico; de Carvalho Marques, Beatriz; Sacchetto, Lívia; Sepedro Lima, Ana Karoline; Pereira Parra, Maisa Carla; Jeronimo Lima, Alex Ranieri; Ribeiro, Gabriela; Jorge Martins, Antonio; Dos Santos Barros, Claudia Renata; Carolina Elias, Maria; Coccuzzo Sampaio, Sandra; Nanev Slavov, Svetoslav; Strazza Rodrigues, Evandra; Vieira Santos, Elaine; Tadeu Covas, Dimas; Kashima, Simone; Augusto Brassaloti, Ricardo; Petry, Bruna; Gaspar Clemente, Luan; Lehmann Coutinho, Luiz; Akemi Assato, Patricia; da Silva da Costa, Felipe Allan; Souza-Neto, Jayme A; Maria Tommasini Grotto, Rejane; Daiana Poleti, Mirele; Cristina Chagas Lesbon, Jessika; Chicaroni Mattos, Elisangela; Fukumasu, Heidge; Giovanetti, Marta; Carlos Junior Alcantara, Luiz; Rahal, Paula; Pessoa Araújo, João Fernando; Althouse, Benjamin M; Vasilakis, Nikos; Lacerda Nogueira, Maurício.
Afiliação
  • Banho CA; Laboratório de Pesquisas em Virologia, Faculdade de Medicina de São José do Rio Preto; São José do Rio Preto, São Paulo, Brazil.
  • de Carvalho Marques B; Laboratório de Pesquisas em Virologia, Faculdade de Medicina de São José do Rio Preto; São José do Rio Preto, São Paulo, Brazil.
  • Sacchetto L; Laboratório de Pesquisas em Virologia, Faculdade de Medicina de São José do Rio Preto; São José do Rio Preto, São Paulo, Brazil.
  • Sepedro Lima AK; Laboratório de Pesquisas em Virologia, Faculdade de Medicina de São José do Rio Preto; São José do Rio Preto, São Paulo, Brazil.
  • Pereira Parra MC; Laboratório de Pesquisas em Virologia, Faculdade de Medicina de São José do Rio Preto; São José do Rio Preto, São Paulo, Brazil.
  • Jeronimo Lima AR; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Ribeiro G; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Jorge Martins A; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Dos Santos Barros CR; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Carolina Elias M; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Coccuzzo Sampaio S; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Nanev Slavov S; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Strazza Rodrigues E; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Vieira Santos E; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Tadeu Covas D; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Kashima S; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo, Brazil.
  • Augusto Brassaloti R; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Petry B; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Gaspar Clemente L; University of São Paulo, Centro de Genômica Funcional da ESALQ, Piracicaba, SP, Brazil.
  • Lehmann Coutinho L; University of São Paulo, Centro de Genômica Funcional da ESALQ, Piracicaba, SP, Brazil.
  • Akemi Assato P; University of São Paulo, Centro de Genômica Funcional da ESALQ, Piracicaba, SP, Brazil.
  • da Silva da Costa FA; University of São Paulo, Centro de Genômica Funcional da ESALQ, Piracicaba, SP, Brazil.
  • Souza-Neto JA; São Paulo State University (UNESP), School of Agricultural Sciences, Department of Bioprocesses and Biotechnology, Botucatu, Brazil.
  • Maria Tommasini Grotto R; São Paulo State University (UNESP), School of Agricultural Sciences, Department of Bioprocesses and Biotechnology, Botucatu, Brazil.
  • Daiana Poleti M; São Paulo State University (UNESP), School of Agricultural Sciences, Botucatu, Brazil.
  • Cristina Chagas Lesbon J; São Paulo State University (UNESP), School of Agricultural Sciences, Botucatu, Brazil.
  • Chicaroni Mattos E; Molecular Biology Laboratory, Applied Biotechnology Laboratory, Clinical Hospital of the Botucatu Medical School, Brazil.
  • Fukumasu H; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
  • Giovanetti M; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
  • Carlos Junior Alcantara L; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
  • Rahal P; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
  • Pessoa Araújo JF; Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil.
  • Althouse BM; Climate Amplified Diseases And Epidemics (CLIMADE), Brazil, Americas.
  • Vasilakis N; Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Italy.
  • Lacerda Nogueira M; Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil.
Res Sq ; 2024 Jan 22.
Article em En | MEDLINE | ID: mdl-38343798
ABSTRACT
Since 2021, the emergence of variants of concern (VOC) has led Brazil to experience record numbers of in COVID-19 cases and deaths. The expanded spread of the SARS-CoV-2 combined with a low vaccination rate has contributed to the emergence of new mutations that may enhance viral fitness, leading to the persistence of the disease. Due to limitations in the real-time genomic monitoring of new variants in some Brazilian states, we aimed to investigate whether genomic surveillance, coupled with epidemiological data and SARS-CoV-2 variants spatiotemporal spread in a smaller region, can reflect the pandemic progression at a national level. Our findings revealed three SARS-CoV-2 variant replacements from 2021 to early 2022, corresponding to the introduction and increase in the frequency of Gamma, Delta, and Omicron variants, as indicated by peaks of the Effective Reproductive Number (Reff). These distinct clade replacements triggered two waves of COVID-19 cases, influenced by the increasing vaccine uptake over time. Our results indicated that the effectiveness of vaccination in preventing new cases during the Delta and Omicron circulations was six and eleven times higher, respectively, than during the period when Gamma was predominant, and it was highly efficient in reducing the number of deaths. Furthermore, we demonstrated that genomic monitoring at a local level can reflect the national trends in the spread and evolution of SARS-CoV-2.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Res Sq Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Res Sq Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos