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Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach.
Fernandes, Diégina Araújo; Gomes, Ayala Nara Pereira; da Silva, Camila Macaubas; de Medeiros Henriques, Isabelly Soares; de Menezes, Renata Priscila Barros; Scotti, Marcus Tullius; Teles, Yanna Carolina Ferreira; Edrada-Ebel, RuAngelie; de Fatima Vanderlei de Souza, Maria.
Afiliação
  • Fernandes DA; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba, João Pessoa, Brazil.
  • Gomes ANP; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba, João Pessoa, Brazil.
  • da Silva CM; Post Graduation Program in Development and Technological Innovation in Medicines, Federal University of Paraiba, João Pessoa, Brazil.
  • de Medeiros Henriques IS; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba, João Pessoa, Brazil.
  • de Menezes RPB; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba, João Pessoa, Brazil.
  • Scotti MT; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba, João Pessoa, Brazil.
  • Teles YCF; Department of Chemistry and Physics, Agrarian Sciences Center, Federal University of Paraiba, Areia, Brazil.
  • Edrada-Ebel R; Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, U.K.
  • de Fatima Vanderlei de Souza M; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba, João Pessoa, Brazil.
Curr Med Chem ; 31(26): 4138-4159, 2024.
Article em En | MEDLINE | ID: mdl-38375850
ABSTRACT

BACKGROUND:

Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessel diseases. Several studies have been conducted to identify antithrombotic agents from medicinal plants, and phenolic compounds (PCs) have been shown to effectively inhibit plasma coagulation and platelet aggregation.

OBJECTIVES:

This study aimed to conduct a survey of the natural PCs with proven antithrombotic and antiplatelet activities, as well as to evaluate by computational modeling the physicochemical and toxicological properties of these compounds using drug-likeness approaches.

METHODS:

The data were collected from the scientific database 'Web of Science', 'Scifinder', 'Pubmed', 'ScienceDirect' and 'Google Scholar', the different classes of PCs with antithrombotic or antiplatelet effects were used as keywords. These molecules were also evaluated for their Drug-Likeness properties and toxicity to verify their profile for being candidates for new antithrombotic drugs.

RESULTS:

In this review, it was possible to register 85 lignans, 73 flavonoids, 28 coumarins, 21 quinones, 23 phenolic acids, 8 xanthones and 8 simple phenols. Activity records for tannins were not found in the researched databases. Of these 246 compounds, 213 did not violate any of Lipinski's rules of five, of which 125 (59%) showed non-toxicity, being promising candidates for new potential antithrombotic drugs.

CONCLUSION:

This review arouses interest in the isolation of phenolic compounds that may allow a new approach for the prevention of both arterial and venous thrombosis, with the potential to become alternatives in the prevention and treatment of cardiovascular diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Inibidores da Agregação Plaquetária / Fibrinolíticos Limite: Animals / Humans Idioma: En Revista: Curr Med Chem Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Inibidores da Agregação Plaquetária / Fibrinolíticos Limite: Animals / Humans Idioma: En Revista: Curr Med Chem Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos