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LaSap vaccine: Immunotherapy and immunochemotherapy associated with allopurinol in dogs naturally infected with Leishmania infantum.
Clasta, Ricardo B; Rivas, Açucena Veleh; Souza, Adrieli Barboza; Dos Santos, Angelo G V; Le Quesne, Andrés Hernán Mojoli; Gonçalves, Ana Alice Maia; Cangussu, Alex Sander R; Giunchetti, Rodolfo C; Viana, Kelvinson F.
Afiliação
  • Clasta RB; Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu, Brazil.
  • Rivas AV; Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu, Brazil.
  • Souza AB; Department of Clinical Analysis, Center for Tropical Medicine, Foz do Iguaçu, Brazil.
  • Dos Santos AGV; Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu, Brazil.
  • Le Quesne AHM; Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu, Brazil.
  • Gonçalves AAM; Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu, Brazil.
  • Cangussu ASR; Department of Medicine, Catholic University of Alto Paraná, Ciudad del Este, Paraguay.
  • Giunchetti RC; Laboratory of Biology of Cellular Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Viana KF; Department of Bioprocess Engineering and Biotechnology, Federal University of Tocantins, Gurupi, Brazil.
Parasite Immunol ; 46(2): e13028, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38389494
ABSTRACT
Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs stable for long periods, and the risk of generating parasitic resistance must be considered. Forty-four symptomatic and naturally infected dogs with Leishmania infantum were tested with two treatment protocols (i) immunotherapy with LaSap vaccine and (ii) immunochemotherapy with LaSap vaccine plus allopurinol. At 90 days after the end of the treatment, it was verified that, although both protocols had generated significant clinical improvements with a greater production of IFN-γ/IL-10, in relation to the parasite load, mainly in the skin, the dogs treated only with immunotherapy maintained the same profile. These results indicate that LaSap is a good strategy to control dog parasitism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Leishmania infantum / Doenças do Cão / Leishmaniose Visceral Limite: Animals Idioma: En Revista: Parasite Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Leishmania infantum / Doenças do Cão / Leishmaniose Visceral Limite: Animals Idioma: En Revista: Parasite Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido