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Interactions Between the Ubiquitin-Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence.
Monsalvo-Maraver, Luis Angel; Ovalle-Noguez, Enid A; Nava-Osorio, Jade; Maya-López, Marisol; Rangel-López, Edgar; Túnez, Isaac; Tinkov, Alexey A; Tizabi, Yousef; Aschner, Michael; Santamaría, Abel.
Afiliação
  • Monsalvo-Maraver LA; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico. luismonsalvo@ciencias.unam.mx.
  • Ovalle-Noguez EA; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico.
  • Nava-Osorio J; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico.
  • Maya-López M; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico.
  • Rangel-López E; Doctorado en Ciencias Biológicas y de La Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico.
  • Túnez I; Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico City, Mexico.
  • Tinkov AA; Instituto de Investigaciones Biomédicas Maimonides de Córdoba (IMIBIC), Departamento de Bioquímica y Biología Molecular, Facultad de Medicina y Enfermería, Universidad de Córdoba, Red Española de Excelencia en Estimulación Cerebral (REDESTIM), Córdoba, Spain.
  • Tizabi Y; IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Aschner M; Yaroslavl State University, Yaroslavl, Russia.
  • Santamaría A; Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA.
Neurotox Res ; 42(2): 18, 2024 Feb 23.
Article em En | MEDLINE | ID: mdl-38393521
ABSTRACT
Neurodegenerative disorders are chronic brain diseases that affect humans worldwide. Although many different factors are thought to be involved in the pathogenesis of these disorders, alterations in several key elements such as the ubiquitin-proteasome system (UPS), the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, and the endocannabinoid system (ECS or endocannabinoidome) have been implicated in their etiology. Impairment of these elements has been linked to the origin and progression of neurodegenerative disorders, while their potentiation is thought to promote neuronal survival and overall neuroprotection, as proved with several experimental models. These key neuroprotective pathways can interact and indirectly activate each other. In this review, we summarize the neuroprotective potential of the UPS, ECS, and Nrf2 signaling, both separately and combined, pinpointing their role as a potential therapeutic approach against several hallmarks of neurodegeneration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Complexo de Endopeptidases do Proteassoma Limite: Humans Idioma: En Revista: Neurotox Res Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Complexo de Endopeptidases do Proteassoma Limite: Humans Idioma: En Revista: Neurotox Res Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos