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Use of Callistemon citrinus as a gastroprotective and anti-inflammatory agent on indomethacin-induced gastric ulcers in obese rats.
Piñón-Simental, Jonathan Saúl; Ayala-Ruiz, Luis Alberto; Ortega-Pérez, Luis Gerardo; Magaña-Rodríguez, Oliver Rafid; Meléndez-Herrera, Esperanza; Aguilera-Méndez, Asdrubal; Rios-Chavez, Patricia.
Afiliação
  • Piñón-Simental JS; Biologia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
  • Ayala-Ruiz LA; Biologia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
  • Ortega-Pérez LG; Biologia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
  • Magaña-Rodríguez OR; Biologia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
  • Meléndez-Herrera E; Instituto de Investigaciones sobre los Recursos Naturales, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
  • Aguilera-Méndez A; Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
  • Rios-Chavez P; Biologia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacan, Mexico.
PeerJ ; 12: e17062, 2024.
Article em En | MEDLINE | ID: mdl-38435992
ABSTRACT

Background:

Obesity leads to an elevated risk of developing gastrointestinal disease such as gastric ulcers. Callistemon citrinus leaf extract has shown antioxidant, antimicrobial, hepatoprotective, and chemoprotective effects against colon cancer. The aim of this study is to evaluate the gastroprotective effect of C. citrinus leaf extract on indomethacin-induced gastric ulcers in obese rats.

Methods:

Gastric ulcers were induced in female obese Wistar rats using a single oral dose of indomethacin (IND). In the first stage, the rats were fed with a high fat sugar diet (HFSD) for 15 weeks to induce obesity and, at the same time, the diet of the other group of animals included daily administration of ethanolic C. citrinus leaf extract (250 mg/kg) in addition to HFSD. In the second stage, gastric ulcers were induced with IND (30 mg/kg). The gastroprotective activity of C. citrinus, the inflammatory enzyme activities, and cytokines in the stomach were determined.

Results:

C. citrinus produced a reduction of gastric lesions caused by IND. Myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), and 5-lipoxygenase (5-LOX) activities also decreased. Although inflammatory biomarkers such as TNFα, IL-6, AOPP, and leptin were significantly decreased by C. citrinus, adiponectin levels increased. Moreover, C. citrinus decreased weight gain and morphological and biochemical parameters.

Conclusion:

The use of indomethacin in rats fed with a high fat-sugar diet increased gastric ulcers. Gastroprotective effect of C. citrinus in obese rats is attributed to the reduction of pro-inflammatory cytokines and the inflammatory enzymes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Úlcera Gástrica / Indometacina Limite: Animals Idioma: En Revista: PeerJ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Úlcera Gástrica / Indometacina Limite: Animals Idioma: En Revista: PeerJ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos