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Interaction between PTSD-PRS and trauma affects PTSD likelihood in women victims of sexual assault.
Bugiga, Amanda Victória Gomes; Carvalho, Carolina Muniz; Oliveira, Adrielle Martins; Coimbra, Bruno Messina; Chehimi, Samar Nasser; Zanardo, Evelin Aline; Kulikowski, Leslie Domenici; Mello, Andrea Feijó; Ota, Vanessa Kiyomi; Mello, Marcelo Feijo; Belangero, Sintia Iole.
Afiliação
  • Bugiga AVG; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo, Brazil. Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, Brazil. Post-Graduation Program in Structural and Functional Biology, Universidade Federal de São Paulo, Brazil.
  • Carvalho CM; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo, Brazil. Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, Brazil. Post-Graduation Program in Psychiatry and Medical Psychology, Universidade Federal de São Paulo, Brazil.
  • Oliveira AM; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo, Brazil. Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, Brazil. Post-Graduation Program in Psychiatry and Medical Psychology, Universidade Federal de São Paulo, Brazil.
  • Coimbra BM; Post-Graduation Program in Psychiatry and Medical Psychology, Universidade Federal de São Paulo, Brazil. Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute and Amsterdam Neuroscience Research Institute, The Netherlands.
  • Chehimi SN; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
  • Zanardo EA; Hospital das Clínicas, Faculty of Medicine, Cytogenomic Laboratory, Universidade de São Paulo, Brazil.
  • Kulikowski LD; Hospital das Clínicas, Faculty of Medicine, Cytogenomic Laboratory, Universidade de São Paulo, Brazil.
  • Mello AF; Post-Graduation Program in Psychiatry and Medical Psychology, Universidade Federal de São Paulo, Brazil.
  • Ota VK; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo, Brazil. Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, Brazil.
  • Mello MF; Post-Graduation Program in Psychiatry and Medical Psychology, Universidade Federal de São Paulo, Brazil. Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil.
  • Belangero SI; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo, Brazil. Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, Brazil. Post-Graduation Program in Psychiatry and Medical Psychology, Universidade Federal de São Paulo, Brazil. Post-Gradua
Braz J Psychiatry ; 2024 Mar 11.
Article em En | MEDLINE | ID: mdl-38467473
ABSTRACT

OBJECTIVE:

Post-traumatic stress disorder (PTSD) is triggered by traumatic events, but genetic vulnerability and a history of childhood trauma are additional factors that may increase the risk of PTSD. Thus, our study focused on exploring the interaction between genetic susceptibility, as assessed by polygenic risk score (PRS), and traumatic events.

METHODS:

We evaluated 68 women with PTSD who had been sexually assaulted and 63 healthy controls without a history of sexual assault. DNA was genotyped using the Infinium Global Screening Array (Illumina), and PRS analysis was performed using PRSice. Furthermore, logistic regression models were employed to examine the interaction between childhood trauma, traumatic life events, and PTSD-PRS and how they contribute to the risk of developing PTSD.

RESULTS:

We found a significant association between PRS, childhood trauma (p = 0.03; OR = 1.241), and PTSD. Additionally, an interaction was observed between PRS, traumatic life events, and childhood trauma, particularly relating to physical and emotional neglect (p = 0.028; OR = 1.010). When examining neglect separately, we found a modest association between emotional neglect and PTSD (p = 0.014; OR = 1.086).

CONCLUSIONS:

Our findings highlight the importance of considering genetic vulnerability and traumatic experiences in understanding the etiology of PTSD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil