Your browser doesn't support javascript.
loading
SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis.
Baxter, Ryan M; Cabrera-Martinez, Berenice; Ghosh, Tusharkanti; Rester, Cody; Moreno, Miguel Guerrero; Borko, Tyler L; Selva, Sean; Fleischer, Chelsie L; Haakonsen, Nicola; Mayher, Ariana; Bowhay, Emily; Evans, Courtney; Miller, Todd M; Huey, Leah; McWilliams, Jennifer; van Bokhoven, Adrie; Deane, Kevin D; Knight, Vijaya; Jordan, Kimberly R; Ghosh, Debashis; Klarquist, Jared; Kedl, Ross M; Piquet, Amanda L; Hsieh, Elena W Y.
Afiliação
  • Baxter RM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Cabrera-Martinez B; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Ghosh T; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO.
  • Rester C; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Moreno MG; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Borko TL; Department of Neurology, Sections of Neuroimmunology, Neuroinfectious Disease, and Neurohospitalist, University of Colorado School of Medicine, Aurora, CO.
  • Selva S; Department of Neurology, Sections of Neuroimmunology, Neuroinfectious Disease, and Neurohospitalist, University of Colorado School of Medicine, Aurora, CO.
  • Fleischer CL; Department of Medicine, Division of Rheumatology, University of Colorado, School of Medicine, Aurora, CO.
  • Haakonsen N; Department of Medicine, Division of Infectious Diseases, University of Colorado, School of Medicine, Aurora, CO.
  • Mayher A; Allergy and Immunology Research, Research Institute, Children's Hospital Colorado, Aurora, CO.
  • Bowhay E; Allergy and Immunology Research, Research Institute, Children's Hospital Colorado, Aurora, CO.
  • Evans C; Allergy and Immunology Research, Research Institute, Children's Hospital Colorado, Aurora, CO.
  • Miller TM; Analytics Resource Center, Children's Hospital Colorado, Aurora, CO.
  • Huey L; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado, School of Medicine, Aurora, CO.
  • McWilliams J; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • van Bokhoven A; Department of Pathology, Section of Pathology Shared Resource, University of Colorado, Aurora, CO.
  • Deane KD; Department of Medicine, Division of Rheumatology, University of Colorado, School of Medicine, Aurora, CO.
  • Knight V; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado, School of Medicine, Aurora, CO.
  • Jordan KR; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Ghosh D; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO.
  • Klarquist J; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Kedl RM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
  • Piquet AL; Department of Neurology, Sections of Neuroimmunology, Neuroinfectious Disease, and Neurohospitalist, University of Colorado School of Medicine, Aurora, CO.
  • Hsieh EWY; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
Immunohorizons ; 8(3): 254-268, 2024 Mar 01.
Article em En | MEDLINE | ID: mdl-38483384
ABSTRACT
The impact of B cell deficiency on the humoral and cellular responses to SARS-CoV2 mRNA vaccination remains a challenging and significant clinical management question. We evaluated vaccine-elicited serological and cellular responses in 1) healthy individuals who were pre-exposed to SARS-CoV-2 (n = 21), 2) healthy individuals who received a homologous booster (mRNA, n = 19; or Novavax, n = 19), and 3) persons with multiple sclerosis on B cell depletion therapy (MS-αCD20) receiving mRNA homologous boosting (n = 36). Pre-exposure increased humoral and CD4 T cellular responses in immunocompetent individuals. Novavax homologous boosting induced a significantly more robust serological response than mRNA boosting. MS-α CD20 had an intact IgA mucosal response and an enhanced CD8 T cell response to mRNA boosting compared with immunocompetent individuals. This enhanced cellular response was characterized by the expansion of only effector, not memory, T cells. The enhancement of CD8 T cells in the setting of B cell depletion suggests a regulatory mechanism between B and CD8 T cell vaccine responses.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Esclerose Múltipla Limite: Humans Idioma: En Revista: Immunohorizons Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Esclerose Múltipla Limite: Humans Idioma: En Revista: Immunohorizons Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos