Your browser doesn't support javascript.
loading
Exploring the antioxidant potential of chalcogen-indolizines throughout in vitro assays.
Garcia, Cleisson Schossler; da Rocha, Marcia Juciele; Presa, Marcelo Heinemann; Pires, Camila Simões; Besckow, Evelyn Mianes; Penteado, Filipe; Gomes, Caroline Signorini; Lenardão, Eder João; Bortolatto, Cristiani Folharini; Brüning, César Augusto.
Afiliação
  • Garcia CS; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • da Rocha MJ; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Presa MH; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Pires CS; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Besckow EM; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Penteado F; Department of Chemistry, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
  • Gomes CS; Laboratory of Clean Organic Synthesis (LASOL), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Lenardão EJ; Laboratory of Clean Organic Synthesis (LASOL), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Bortolatto CF; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Brüning CA; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
PeerJ ; 12: e17074, 2024.
Article em En | MEDLINE | ID: mdl-38500528
ABSTRACT
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are highly reactive molecules produced naturally by the body and by external factors. When these species are generated in excessive amounts, they can lead to oxidative stress, which in turn can cause cellular and tissue damage. This damage is known to contribute to the aging process and is associated with age-related conditions, including cardiovascular and neurodegenerative diseases. In recent years, there has been an increased interest in the development of compounds with antioxidant potential to assist in the treatment of disorders related to oxidative stress. In this way, compounds containing sulfur (S) and/or selenium (Se) have been considered promising due to the relevant role of these elements in the biosynthesis of antioxidant enzymes and essential proteins with physiological functions. In this context, studies involving heterocyclic nuclei have significantly increased, notably highlighting the indolizine nucleus, given that compounds containing this nucleus have been demonstrating considerable pharmacological properties. Thus, the objective of this research was to evaluate the in vitro antioxidant activity of eight S- and Se-derivatives containing indolizine nucleus and different substituents. The in vitro assays 1,1-diphenyl-2-picryl-hydrazil (DPPH) scavenger activity, ferric ion (Fe3+) reducing antioxidant power (FRAP), thiobarbituric acid reactive species (TBARS), and protein carbonylation (PC) were used to access the antioxidant profile of the compounds. Our findings demonstrated that all the compounds showed FRAP activity and reduced the levels of TBARS and PC in mouse brains homogenates. Some compounds were also capable of acting as DPPH scavengers. In conclusion, the present study demonstrated that eight novel organochalcogen compounds exhibit antioxidant activity.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selênio / Antioxidantes Limite: Animals Idioma: En Revista: PeerJ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selênio / Antioxidantes Limite: Animals Idioma: En Revista: PeerJ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos