Your browser doesn't support javascript.
loading
The rs2018736 fibulin-5 polymorphism as a determinant for pelvic organ prolapse: a case-control study.
Teixeira, Juliana B; Bortolini, Maria A T; Silva, Rebecca S P; Batista, Nilce C; Costa E Silva, Carolina L; Allen-Brady, Kristina; Castro, Rodrigo A.
Afiliação
  • Teixeira JB; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, SP, Brazil.
  • Bortolini MAT; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, SP, Brazil.
  • Silva RSP; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, SP, Brazil.
  • Batista NC; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, SP, Brazil.
  • Costa E Silva CL; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, SP, Brazil.
  • Allen-Brady K; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
  • Castro RA; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, SP, Brazil.
Climacteric ; 27(3): 321-325, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38533754
ABSTRACT

OBJECTIVE:

Fibulin-5 is a connective tissue component and may play a role in pelvic organ prolapse (POP) pathogenesis. This study aimed to verify the association of the rs2018736 polymorphism of the fibulin-5 gene with POP in postmenopausal Brazilian women, and to determine the risk factors for POP.

METHOD:

This observational, cross-sectional, case-control study assessed postmenopausal women with advanced POP (stages III and IV) and control women (stages 0 and I) by examination and peripheral blood sample collection. DNA sequences were analyzed by real-time reverse-transcriptase polymerase chain reaction. A logistic regression model was used with p < 0.05 for significance.

RESULTS:

A total of 565 participants were evaluated (325 POP and 240 control). The homozygous C allele of rs2018736 (CC) was protective against POP (odds ratio [OR] 0.49, 95% confidence interval [CI] 0.26-0.91). Age (OR 1.09, 95% CI 1.05-1.13), number of pregnancies (OR 1.14, 95% CI 1.01-1.28), vaginal delivery (OR 5.32, 95% CI 2.58-11.01), forceps delivery (OR 3.34, 95% CI 1.72-6.47), weight of newborn (OR 1.0007, 95% CI 1.0002-1.0011), family history of POP (OR 2.35, 95% CI 1.24-4.44), hypertension (OR 1.74, 95% CI 1.01-3.00) and diabetes (OR 2.19, 95% CI 1.07-4.48)] were independent predictors for POP; cesarean (OR 0.02, 95% CI 0.005-0.09) was protective.

CONCLUSION:

The rs2018736-CC genotype of the fibulin-5 gene has a protective role against POP.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas da Matriz Extracelular / Pós-Menopausa / Polimorfismo de Nucleotídeo Único / Prolapso de Órgão Pélvico Limite: Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Climacteric Assunto da revista: GINECOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas da Matriz Extracelular / Pós-Menopausa / Polimorfismo de Nucleotídeo Único / Prolapso de Órgão Pélvico Limite: Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Climacteric Assunto da revista: GINECOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido