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Human Papillomavirus (HPV) Infection and Risk Behavior in Vaccinated and Non-Vaccinated Paraguayan Young Women.
Bobadilla, María Liz; Villagra, Verónica; Castro, Héctor; von Horoch, Marta; Araya, Soraya; Deluca, Gerardo; de Paula, Vanessa Salete.
Afiliação
  • Bobadilla ML; Laboratory of Immunology, Central Laboratory of Public Health, Minister of Public Health and Social Welfare, Asunción 1429, Paraguay.
  • Villagra V; Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil.
  • Castro H; Laboratory of Immunology, Central Laboratory of Public Health, Minister of Public Health and Social Welfare, Asunción 1429, Paraguay.
  • von Horoch M; Expanded Immunization Program, Minister of Public Health and Social Welfare, Asunción 1429, Paraguay.
  • Araya S; Expanded Immunization Program, Minister of Public Health and Social Welfare, Asunción 1429, Paraguay.
  • Deluca G; Expanded Immunization Program, Minister of Public Health and Social Welfare, Asunción 1429, Paraguay.
  • de Paula VS; Molecular Applications Laboratory, Faculty of Medicine, Northeast National University, Corrientes 1240, Argentina.
Pathogens ; 13(3)2024 Feb 27.
Article em En | MEDLINE | ID: mdl-38535552
ABSTRACT
Cervical cancer is a global health concern and ranks fourth among the most prevalent cancers in women worldwide. Human papillomavirus (HPV) infection is a known precursor of cervical cancer and preventive measures include prophylactic vaccines. This study focused on sexually active Paraguayan women aged 18-25 years, exploring the intersection of HPV vaccination and sexual behavior. Among 254 participants, 40.9% received the Gardasil-4 vaccine, with no significant differences in sexual behavior between the vaccinated and unvaccinated sexually active groups. However, a notable decrease in the prevalence of HPV among the vaccinated women highlights the efficacy of this vaccine in reducing infections. The prevalence of any HPV type was 37.5% in vaccinated participants compared to 56.7% in unvaccinated participants (p = 0.0026). High-risk HPV types showed a significant difference, with a prevalence of 26.0% in vaccinated women compared with 52.7% in unvaccinated women (p < 0.001). Although a potential decline in genital warts was observed among the vaccinated individuals, statistical significance (p = 0.0564) was not reached. Despite the challenges in achieving high vaccination coverage, the observed reduction in HPV prevalence underscores the importance of ongoing monitoring, healthcare professional recommendations, and comprehensive risk management. These findings contribute to dispelling concerns about HPV vaccination influencing sexual behavior, advocating further large-scale research to explore the impact of vaccines on various HPV types and potential cross-protection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Paraguay Idioma: En Revista: Pathogens Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Paraguai País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Paraguay Idioma: En Revista: Pathogens Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Paraguai País de publicação: Suíça