Your browser doesn't support javascript.
loading
Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders.
Camberos-Barraza, Josué; Camacho-Zamora, Alejandro; Bátiz-Beltrán, José C; Osuna-Ramos, Juan F; Rábago-Monzón, Ángel R; Valdez-Flores, Marco A; Angulo-Rojo, Carla E; Guadrón-Llanos, Alma M; Picos-Cárdenas, Verónica J; Calderón-Zamora, Loranda; Norzagaray-Valenzuela, Claudia D; Cárdenas-Torres, Feliznando I; De la Herrán-Arita, Alberto K.
Afiliação
  • Camberos-Barraza J; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Camacho-Zamora A; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Bátiz-Beltrán JC; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Osuna-Ramos JF; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Rábago-Monzón ÁR; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Valdez-Flores MA; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Angulo-Rojo CE; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Guadrón-Llanos AM; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Picos-Cárdenas VJ; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Calderón-Zamora L; Faculty of Biology, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Norzagaray-Valenzuela CD; Faculty of Biology, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • Cárdenas-Torres FI; Faculty of Nutrition Sciences and Gastronomy, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
  • De la Herrán-Arita AK; Faculty of Medicine, Autonomous University of Sinaloa, Culiacán 80019, Mexico.
Int J Mol Sci ; 25(6)2024 Mar 09.
Article em En | MEDLINE | ID: mdl-38542134
ABSTRACT
The relationship between sleep, glial cells, and the endocannabinoid system represents a multifaceted regulatory network with profound implications for neuroinflammation and cognitive function. The molecular underpinnings of sleep modulation by the endocannabinoid system and its influence on glial cell activity are discussed, shedding light on the reciprocal relationships that govern these processes. Emphasis is placed on understanding the role of glial cells in mediating neuroinflammatory responses and their modulation by sleep patterns. Additionally, this review examines how the endocannabinoid system interfaces with glia-immune signaling to regulate inflammatory cascades within the central nervous system. Notably, the cognitive consequences of disrupted sleep, neuroinflammation, and glial dysfunction are addressed, encompassing implications for neurodegenerative disorders, mood disturbances, and cognitive decline. Insights into the bidirectional modulation of cognitive function by the endocannabinoid system in the context of sleep and glial activity are explored, providing a comprehensive perspective on the potential mechanisms underlying cognitive impairments associated with sleep disturbances. Furthermore, this review examines potential therapeutic avenues targeting the endocannabinoid system to mitigate neuroinflammation, restore glial homeostasis, and normalize sleep patterns. The identification of novel therapeutic targets within this intricate regulatory network holds promise for addressing conditions characterized by disrupted sleep, neuroinflammation, and cognitive dysfunction. This work aims to examine the complexities of neural regulation and identify potential avenues for therapeutic intervention.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Sono-Vigília / Endocanabinoides Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Sono-Vigília / Endocanabinoides Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça