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Double vitrification of embryos adversely affects clinical outcomes.
Oraiopoulou, Chara; Karagianni, Mary; Papatheodorou, Achilleas; Toumpa, Olga; Papadopoulou, Marianna; Christophoridis, Nicholaos; Drakopoulos, Panagiotis; Chatziparasidou, Alexia.
Afiliação
  • Oraiopoulou C; Embryology Department, Embryolab Fertility Clinic, Thessaloniki, Greece.
  • Karagianni M; Embryolab Academy, Thessaloniki, Greece.
  • Papatheodorou A; Embryolab Academy, Thessaloniki, Greece.
  • Toumpa O; Embryology Department, Embryolab Fertility Clinic, Thessaloniki, Greece.
  • Papadopoulou M; Embryolab Academy, Thessaloniki, Greece.
  • Christophoridis N; Embryology Department, Embryolab Fertility Clinic, Thessaloniki, Greece.
  • Drakopoulos P; Embryology Department, Embryolab Fertility Clinic, Thessaloniki, Greece.
  • Chatziparasidou A; Embryolab Academy, Thessaloniki, Greece.
JBRA Assist Reprod ; 28(3): 399-404, 2024 Aug 26.
Article em En | MEDLINE | ID: mdl-38546119
ABSTRACT

OBJECTIVE:

To evaluate the impact of double embryo vitrification on clinical outcomes.

METHODS:

This retrospective cohort study included data from January 2013 to March 2021. The study group included women aged 33.3±5.7 years with double-vitrified embryos (n=381), while the control group included women aged 32.1±6.7 years with embryos vitrified once (n=780), all transferred at the blastocyst stage. The primary endpoint was live birth rate (LBR), and secondary endpoints included percent positive ßHCG test, clinical/ongoing pregnancy rates, miscarriage/biochemical pregnancy rates and birthweight.

RESULTS:

LBR was significantly lower in double-vitrified embryos (30.2%) than in embryos vitrified once (45.6%, p<.05). Similarly, double-vitrified embryos were associated with significantly lower positive ßHCG tests (46% vs. 63.3%, p<.05) and clinical (34.9% vs. 52.2%, p<.05) and ongoing pregnancy (31.3% vs. 47.3%, p<.05) rates compared to embryos vitrified once. However, biochemical pregnancy (double vitrified 24.1% vs. vitrified once 17.9%, p>.05) and miscarriage rates (double vitrified 10.2% vs. vitrified once 9.4%, p>.05), as well as mean birthweight (double-vitrified embryos 2950g vs. embryos vitrified once 2837g, p>.05) did not differ significantly between two groups. On a secondary comparison, amongst double-vitrified embryos, the subgroup that was cultured for more than 24 hours between warming and second vitrification achieved significantly higher positive ßHCG tests (49%) and clinical pregnancy (38%) rates, compared to embryos re-vitrified on the same day of warming (31.8% and 20.5%, respectively, p<.05). Nevertheless, LBR did not differ significantly amongst these study-group embryos (embryos that remained in culture for more than 24 hours 32.2% vs. embryos that were re-vitrified on warming day 20.5%, p>.05).

CONCLUSIONS:

Double vitrification of embryos adversely affects clinical outcomes. However, it represents a valuable option concerning embryo wastage, with acceptable success rates.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criopreservação / Transferência Embrionária / Vitrificação Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Grécia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criopreservação / Transferência Embrionária / Vitrificação Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Grécia País de publicação: Brasil