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Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions.
Nóbrega, Jéssica Cavalcante da; Dinallo, Heloíse Rangel; Geraldes, Silvano Salgueiro; Azevedo, Maria Gabriela Picelli de; Moraes, Reiner Silveira de; Maia, Suellen Rodrigues; Souza, Fabiana Ferreira de; Melchert, Alessandra; García, Henry David Mogollón; Andreatti Filho, Raphael Lúcio; Okamoto, Adriano Sakai; Okamoto, Priscylla Tatiana Chalfun Guimarães.
Afiliação
  • Nóbrega JCD; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Dinallo HR; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Geraldes SS; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Azevedo MGP; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Moraes RS; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Maia SR; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Souza FF; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Melchert A; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • García HDM; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Andreatti Filho RL; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Okamoto AS; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil.
  • Okamoto PTCG; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil. tatiana.okamoto@unesp.br.
J Vet Sci ; 25(2): e27, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38568828
ABSTRACT

BACKGROUND:

A urethral obstruction (UO) is an emergency commonly observed in male cats, which can result in significant clinical and laboratory alterations, leading to complications and death.

OBJECTIVES:

This study aimed to correlate symmetric dimethylarginine (SDMA) with the urea, creatinine, potassium, and bicarbonate levels in cats with UO. In addition, the correlation between clinical score and time of obstruction was evaluated.

METHODS:

Thirty male cats were selected and allocated into a control group (CG, n = 13) and an obstruction group (OG, n = 17). The laboratory analyses were conducted before treatment (M0) and at different times after treatment (12 h [M12], 24 h [M24], and 48 h [M48]). Correlations were established between SDMA and creatinine, urea, bicarbonate, potassium, time of obstruction, and the clinical score.

RESULTS:

A strong correlation (r > 0.6) was observed between SDMA and creatinine, urea, and potassium in the OG. Furthermore, there was substantial agreement (kappa value) between SDMA and creatinine at M24. A higher clinical score was associated with a longer time of obstruction. In the OG, at M48, the SDMA and creatinine levels were 50% and 41.2% higher, respectively.

CONCLUSIONS:

A correlation was observed between SDMA and creatinine in obstructed cats, and significant agreement between these values was observed 24 h after the unblocking treatment. A correlation among SDMA, urea, and potassium was observed. Approximately 9% more cats continued to have elevated SDMA levels after 48 h of treatment compared to creatinine. This suggests a slightly lower sensitivity of the latter biomarker but does not exclude the possibility of congruent and normalized values after a longer evaluation period.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Doenças do Gato / Insuficiência Renal Crônica Limite: Animals Idioma: En Revista: J Vet Sci Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação:
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Doenças do Gato / Insuficiência Renal Crônica Limite: Animals Idioma: En Revista: J Vet Sci Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: